Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Maximizing Extubation Outcomes Through Educational and Organizational Research (METEOR) Trial
Sponsor: University of Pittsburgh
Summary
The METEOR Trial will compare four implementation strategies-traditional online education, protocol-directed care, interprofessional education, and a combination of protocol-directed care and interprofessional education-to test the hypotheses that interprofessional education is superior to traditional online education as an implementation strategy in the intensive care unit (ICU) and the benefits of interprofessional education are increased when interprofessional education is paired with a clinical protocol. Additionally, the trial will also test the hypothesis that preventive post-extubation NIV for high-risk patients and preventive post-extubation HFNC for low-risk patients are both superior to current clinical practice (i.e., conventional post-extubation oxygen therapy).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
13018
Start Date
2023-03-01
Completion Date
2026-04
Last Updated
2026-02-18
Healthy Volunteers
No
Interventions
Traditional online education
A 30-60 minute, online, interactive, educational video that is customized to each provider type and offered with provider-specific continuing education credits
Interprofessional education
Interprofessional education (IPE) consists of both classroom-based IPE and just-in-time IPE. In classroom-based IPE, a trained physician educator with content expertise who works in the ICU leads a 60-to-90-minute, in-person, IPE workshop consisting of a 30-minute didactic session and a 30-to-60-minute small group session, during which participants work together to apply the content to authentic cases. The workshops, which are designed according to modern principles of adult learning and IPE, present the rationale and evidence supporting the preventive, post-extubation therapies. They are specifically designed to foster authenticity, reinforce role identity, and relate the content to life experience. In just-in-time IPE, trained local champions meet with the interprofessional ICU team each morning to identify eligible patients and, as needed, briefly review the evidence supporting proper use of the assigned preventive, post-extubation strategy.
Clinical protocol
An "adequately explicit" protocol provides specific rules for use of the preventive, post-extubation therapy based on patient data. A "ready-to-customize" version of the protocol with instructions to work with key local stakeholders to revise the protocol, accounting for local needs and resources, is provided. After local customization, a local champion then disseminates the protocol based on local practices.
Risk-stratified preventive post-extubation noninvasive ventilation (NIV) or high-flow nasal cannula oxygen (HFNC)
Preventive post-extubation NIV for high-risk patients and preventive post-extubation HFNC for low-risk patients
Preventive post-extubation high-flow nasal cannula oxygen (HFNC)
Preventive post-extubation HFNC for all eligible patients (without risk stratification)
Locations (15)
UPMC Carlisle
Carlisle, Pennsylvania, United States
UPMC Hanover
Hanover, Pennsylvania, United States
UPMC Harrisburg
Harrisburg, Pennsylvania, United States
UPMC Community Osteopathic
Harrisburg, Pennsylvania, United States
UPMC West Shore
Mechanicsburg, Pennsylvania, United States
UPMC East
Monroeville, Pennsylvania, United States
UPMC Jameson
New Castle, Pennsylvania, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
UPMC Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States
UPMC Presbyterian
Pittsburgh, Pennsylvania, United States
UPMC St. Margaret
Pittsburgh, Pennsylvania, United States
UPMC Mercy
Pittsburgh, Pennsylvania, United States
UPMC Shadyside
Pittsburgh, Pennsylvania, United States
UPMC Passavant
Pittsburgh, Pennsylvania, United States
UPMC Memorial
York, Pennsylvania, United States