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RECRUITING
NCT05523505
NA

Noninvasive Brain Stimulation to Enhance Reading Comprehension Ability in Adults

Sponsor: Vanderbilt University

View on ClinicalTrials.gov

Summary

The goal of this project is to address the urgent need for effective, scalable adult literacy interventions by integrating breakthroughs in two separate fields: 1.) the brain network science of resilience to reading disorders and 2.) high-definition non-invasive brain network stimulation. This study will first establish the efficacy of a novel, noninvasive stimulation protocol on reading behavior and brain metrics; then will determine how stimulation-induced effects interact with baseline reading comprehension ability; and lastly, will identify whether stimulation-induced effects are more clinically-beneficial than canonical behavioral interventions. Results may change the foundation for how we treat low adult literacy, and have the potential for wider reaching impacts on non-invasive stimulation protocols for other clinical disorders.

Official title: Bridging the Gap Between Brain Network Science and High-definition Non-invasive Brain Stimulation to Develop a Scalable Adult Literacy Intervention

Key Details

Gender

All

Age Range

18 Years - 40 Years

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2022-11-07

Completion Date

2026-09-10

Last Updated

2025-08-01

Healthy Volunteers

Yes

Interventions

DEVICE

Sham intervention

Use of the non-invasive brain stimulation device to simulate peripheral experience of stimulation without actually stimulating the brain.

DEVICE

RLN real non-invasive brain stimulation intervention

Real non-invasive brain stimulation to the left angular gyrus using transcranial alternating current stimulation (tACS).

DEVICE

RLN and CCN real non-invasive brain stimulation intervention

Real non-invasive brain stimulation to the left dorsolateral prefrontal cortex and left angular gyrus using transcranial alternating current stimulation (tACS).

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States