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Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
Sponsor: Mayo Clinic
Summary
The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.
Official title: Physiological Regulation of Energy Intake - The FOOD-PRINT Study Identifying the Hormonal and Neural Footprints of the Visceroceptive, Homeostatic, and Hedonic Components of Food Intake Regulation in Humans
Key Details
Gender
All
Age Range
21 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2022-09-08
Completion Date
2028-08
Last Updated
2025-09-18
Healthy Volunteers
Yes
Conditions
Interventions
Functional Magnetic Resonance Imaging (pCASL-MRI)
MRI's will be performed at multiple points on each visit day.
Intragastric Balloon
Intragastric Balloon will be placed during Visit 2 study day and inflated to maximum tolerated volume. Patient will then be scanned in the MRI.
Elemental Meal
Patient will ingest the tasteless elemental meal until their maximum level of fullness. Once full, the patient will be scanned in the MRI.
Hedonic Meal
Patient will ingest meal of their choice from a local food delivery service and eat until they reach their maximum level of fullness. Once full, the patient will be scanned in the MRI
Locations (1)
Mayo Clinic Rochester
Rochester, Minnesota, United States