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RECRUITING
NCT05525845
NA

Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI

Sponsor: Mayo Clinic

View on ClinicalTrials.gov

Summary

The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.

Official title: Physiological Regulation of Energy Intake - The FOOD-PRINT Study Identifying the Hormonal and Neural Footprints of the Visceroceptive, Homeostatic, and Hedonic Components of Food Intake Regulation in Humans

Key Details

Gender

All

Age Range

21 Years - 50 Years

Study Type

INTERVENTIONAL

Enrollment

15

Start Date

2022-09-08

Completion Date

2028-08

Last Updated

2025-09-18

Healthy Volunteers

Yes

Conditions

Interventions

OTHER

Functional Magnetic Resonance Imaging (pCASL-MRI)

MRI's will be performed at multiple points on each visit day.

OTHER

Intragastric Balloon

Intragastric Balloon will be placed during Visit 2 study day and inflated to maximum tolerated volume. Patient will then be scanned in the MRI.

OTHER

Elemental Meal

Patient will ingest the tasteless elemental meal until their maximum level of fullness. Once full, the patient will be scanned in the MRI.

OTHER

Hedonic Meal

Patient will ingest meal of their choice from a local food delivery service and eat until they reach their maximum level of fullness. Once full, the patient will be scanned in the MRI

Locations (1)

Mayo Clinic Rochester

Rochester, Minnesota, United States