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Watchful Waiting for Complete Responders to Therapy in Rectal Cancer
Sponsor: Henry Ford Health System
Summary
The purpose of this project is to determine if in a selected group of patients, at higher risk of wound dehiscence and other complications, treatment by local excision and management by a "watchful waiting" or an initial "non-operative management" approach, with an offer of radical resection only to those patients whose tumors demonstrate "regrowth" will maintain acceptable local control and overall survival rate for the whole cohort.
Official title: Treatment of T2-T3/NO-N+ Adenocarcinoma of the Rectum by Neoadjuvant Chemotherapy (FOLFOX) Followed by Preoperative Chemo (Fluorouracil / Capecitabine)-Radio Therapy (CRT) With Watchful Waiting for Complete Responders
Key Details
Gender
All
Age Range
18 Years - 95 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2018-07-10
Completion Date
2029-07-09
Last Updated
2024-01-29
Healthy Volunteers
No
Conditions
Interventions
Watchfuf waiting
Careful review of patient response with the hope of avoiding radical surgery.
Locations (1)
Ascension St. John Hospital
Detroit, Michigan, United States