Clinical Research Directory

Inclusion Criteria: * patients with locally advanced squamous cell carcinoma of the head and neck (LASCCHN): oral cavity, oropharynx, larynx, hypopharynx, and unknown primary * stage cT4 and/or cN2-N3, with no distant metastases (M0). * Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0-2 * initial clinical staging evaluated in: 1. CT scan or MRI of the neck and CT scan of the chest or 2. FDG18 PET TC Exclusion Criteria: * patients with p16 positive oropharyngeal carcinoma cT0-T3 N2 M0 (stage II), unless extranodal tumor extension * contraindications for cisplatin administration: renal insufficiency (eGFR \< 55ml/min), hearing loss, peripheral neuropathy * dysphagia G\>2 with no percutaneous gastrostomy * the presence of distant metastasis (M1)