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Dental Biofilm Control During Orthodontic Treatment
Sponsor: University of Rijeka
Summary
Orthodontic appliances can affect changes in the relationships of members of the oral microbiome. Microbiome imbalance can result in oral infections and complicate treatment. The focus is on the microbiological profile of dental biofilm and its control. The effects of metals released by corrosion of alloys for oral use on the microbiome and the extent to which they modify the effectiveness of gingivitis therapy by mechanical and chemical control of biofilm will be investigated. Early and late colonizers of the tooth surface will be analyzed. The condition of gingiva will be assessed, and the results will show the specifics of biofilm and gingiva exposed and unexposed, and differences in the response of individual bacteria to therapy. Molecular biology techniques will be used to quantify the total bacterial biomass (16s rRNA) and the proportion of specific bacterial species within the dental biofilm.
Official title: Environmental Factors and Microbiological Interactions in Structure of Dental Biofilm
Key Details
Gender
All
Age Range
13 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2021-11-01
Completion Date
2026-06-01
Last Updated
2026-01-30
Healthy Volunteers
Yes
Conditions
Interventions
fixed metal orthodontic appliance
fixed metal orthodontic appliance (stainless steel brackets (Mini Master MBT 0.022'', American Orthodontics), nickel-titanium archwire (NiTi, American Orthodontics), elastomeric ligatures (Elastomerics, American Orthodontics))
fixed non-metal orthodontic appliance
fixed non-metal orthodontic appliance (ceramic brackets (Radiance MBT 0.022'', American Orthodontics), polyamide thread, elastomeric ligatures (Elastomerics, American Orthodontics))
oral hygiene
conducting regular oral hygiene, commonly recommended for orthodontic patients (toothbrush + toothpaste with a low fluoride concentration of 1450 ppm (Parodontax, GSK)
Chlorhexidine mouthwash
conducting regular oral hygiene (Parodontay, GSK) + 0.12% chlorhexidine digluconate mouthwash (Curasept ADS 212, Curaden) daily during one month
Locations (3)
University of Rijeka Faculty of Dental Medicine
Rijeka, Croatia
University of Rijeka, Faculty od Dental Medicine, Dental Clinic
Rijeka, Croatia
University of Rijeka, Faculty of Dental Medicine
Rijeka, Croatia