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Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia
Sponsor: University Hospital, Basel, Switzerland
Summary
Thiazides and thiazide-like diuretics are one of the five major classes of antihypertensive drugs. This study is to investigate whether urinary PGE2 concentration at baseline (prior to thiazide initiation) is associated with the development of TIH within the first four weeks of treatment.
Official title: Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia: a Prospective Cohort Study (The PROPHECY Study)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
232
Start Date
2022-09-26
Completion Date
2026-07
Last Updated
2025-07-01
Healthy Volunteers
No
Conditions
Interventions
Data and biosample collection
Collection of spot urine, blood sampling, vital parameters, body weight, medical history, patient questionnaires, drinking protocol, drug diary at at Visit 1 (before thiazide initiation), at Optional 2 hours-challenge, at Visit 2 (4 weeks after thiazide initiation), at Visit 2.1 (4 weeks after dose change), at Visit 3 (3-months after thiazide initiation)
Locations (3)
Hospital Universitario de Móstoles
Móstoles, Spain
University Hospital Basel, Endocrinology, Diabetes and Metabolism
Basel, Switzerland
Kantonsspital Baselland
Liestal, Switzerland