Clinical Research Directory

Inclusion Criteria: * Males and females with Fontan physiology * 19 years old at age of enrollment Exclusion Criteria: * Height less than 130 centimeter (cm) * Pregnancy or the plan to become pregnant during the study period * Current intravenous inotropic drugs * Severe ventricular dysfunction assessed qualitatively by clinical echocardiography within six months prior to enrollment * Severe valvar regurgitation, ventricular outflow obstruction, or aortic arch obstruction assessed by clinical echocardiography within six months prior to enrollment * History of arrhythmia with exercise (excluding isolated supraventricular or ventricular ectopy without symptoms) * Inability to complete exercise testing at baseline screening * Noncardiac medical, psychiatric, and/or social disorder that would prevent successful completion of planned study testing or would invalidate its results