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Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases
Sponsor: Istituto Clinico Humanitas
Summary
This is a phase III randomized trial with the aim to compare preoperative HSRS to postoperative HSRS in patients with large at least one BMs from solid tumors suitable for surgical resection.
Official title: Phase III Randomized Trial Comparing Preoperative Hypofractionated Radiosurgery (HSRS) to Postoperative Hypofractionated Radiosurgery (HSRS) for Patients With Large Brain Metastases (= 2.1cm) Suitable for Surgical Resection
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
146
Start Date
2023-01-31
Completion Date
2027-01
Last Updated
2025-04-24
Healthy Volunteers
No
Conditions
Interventions
Hypofractionated Radiosurgery (HSRS)
HSRS converges multiple radiation beams to deliver a single, large dose of radiation to a discrete tumor target with high precision, thereby minimizing radiation dose to the surrounding normal tissue.
Brain metastases surgical resection
Complete surgical resection of brain lesions with adeguate margins.
Locations (9)
ASST Spedali Civili di Brescia
Brescia, Brescia, Italy
AOUC Azienda Ospedaliero-Universitaria Careggi
Florence, Florence, Italy
IRCCS Istituto Clinico Humanitas
Rozzano, Milano, Italy
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Milan, Italy
Ospedale del Mare
Naples, naples, Italy
Policlinico Umberto I
Rome, Rome, Italy
Fondazione Policlinico Universitario Agostino Gemelli
Rome, Rome, Italy
AOU Sant'Andrea
Rome, Rome, Italy
Azienda Ospedaliera Santa Maria di Terni
Terni, Terni, Italy