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Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients
Sponsor: Arkansas Children's Hospital Research Institute
Summary
The participants are being asked to take part in this clinical trial, a type of research study, because the participants are scheduled to receive or have recently received a hematopoietic cell transplant (HCT) or a solid organ transplant (SOT). Primary Objective To determine if pre-transplant screening for respiratory viral load predicts RVI within 1- year post-transplant among survivors. Secondary Objectives: * To develop and validate a classifier based on pre-transplant immunological profile predictive of developing an acute respiratory viral infection (aRVI), with RSV/PIV3/HMPV/SARS-CoV-2 through one-year post-transplant among survivors. * To develop and validate a classifier based on Day +100 post-transplant immunological profiles predictive of developing an acute respiratory viral infection (aRVI),with RSV/PIV3/HMPV/SARS-CoV-2 through one-year post-transplant among survivors .
Key Details
Gender
All
Age Range
Any - 18 Years
Study Type
OBSERVATIONAL
Enrollment
2000
Start Date
2022-12-13
Completion Date
2029-08
Last Updated
2025-10-02
Healthy Volunteers
No
Locations (27)
University of Alabama at Birmingham's (UAB)
Birmingham, Alabama, United States
Arkansas Children's Hospital
Little Rock, Arkansas, United States
Children's National Medical
Washington D.C., District of Columbia, United States
University if Miami
Miami, Florida, United States
Emory and Children's Healthcare of Atlanta
Atlanta, Georgia, United States
University of Chicago Medicine Comer Children's Hospital
Chicago, Illinois, United States
University of Louisville
Louisville, Kentucky, United States
Boston Children's Hospital
Boston, Massachusetts, United States
C.S. Mott Children's Hospital
Ann Arbor, Michigan, United States
Children's Hospital of Michigan
Detroit, Michigan, United States
University of Minnesota
Minneapolis, Minnesota, United States
Washington University
St Louis, Missouri, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
The Children's Hospital at Montefiore
The Bronx, New York, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
Nationwide Children's Hospital
Columbus, Ohio, United States
UPMC
Pittsburgh, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Le Bonheur Children's Hospital
Memphis, Tennessee, United States
St. Jude Children's Research Hospital
Memphis, Tennessee, United States
UT Le Bonheur
Memphis, Tennessee, United States
Cook Children's
Fort Worth, Texas, United States
Baylor College of Medicine
Houston, Texas, United States
MD Anderson Center Center
Houston, Texas, United States
UTHealth Houston
Houston, Texas, United States
Seattle Childrens
Seattle, Washington, United States
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States