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Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant Tuberculosis
Sponsor: University of California, San Francisco
Summary
TS ELiOT is a stepped-wedge, cluster randomized trial assessing the effect of a next-generation sequencing-based strategy on rifampin-resistant tuberculosis management and patient outcomes.
Official title: Targeted Sequencing to Enhance, Liberate, and Optimize Treatment of Drug-resistant Tuberculosis
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
2500
Start Date
2024-08-01
Completion Date
2027-01
Last Updated
2026-01-26
Healthy Volunteers
No
Interventions
Targeted next-generation sequencing
During intervention periods, an additional patient sample derived from routinely collected specimens will be processed by a local technician. Extracted DNA extracted from these samples will be batched on a regular basis for targeted deep sequencing. Sequencing results will be regularly transmitted to a clinical advisory committee.
Locations (1)
South African National Health Laboratory Service
Cape Town, South Africa