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NOT YET RECRUITING
NCT05556499

The Bone-parathyroid Crosstalk in Primary Hyperparathyroidism

Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

View on ClinicalTrials.gov

Summary

The PARABONE study aims to investigate the interaction between bone and parathyroid glands in patients with primary hyperparathyroidism (HPT). The study consists of a clinical part aimed at evaluating a series of circulating molecules of bone derivation (osteocalcin, molecules of the WNT pathway, RANKL, osteoprotegerin, Scelrostin, FGF23) in patients with HPT. In particular, the study has as its primary objective to identify the correlation between circulating levels of PTH and levels of GlaOC and GluOC in patients with HPT.

Official title: Interactions Between Bone and Parathyroid Tumors in Patiens With Primary Hyperparathyroidism (The PARABONE Study)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

100

Start Date

2022-10

Completion Date

2026-06-24

Last Updated

2022-09-30

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

Biomarker assays

Circulating bone biomarkers assays

Locations (1)

IRCCS Istituto Ortopedico Galeazzi

Milan, Italy