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The Bone-parathyroid Crosstalk in Primary Hyperparathyroidism
Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Summary
The PARABONE study aims to investigate the interaction between bone and parathyroid glands in patients with primary hyperparathyroidism (HPT). The study consists of a clinical part aimed at evaluating a series of circulating molecules of bone derivation (osteocalcin, molecules of the WNT pathway, RANKL, osteoprotegerin, Scelrostin, FGF23) in patients with HPT. In particular, the study has as its primary objective to identify the correlation between circulating levels of PTH and levels of GlaOC and GluOC in patients with HPT.
Official title: Interactions Between Bone and Parathyroid Tumors in Patiens With Primary Hyperparathyroidism (The PARABONE Study)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2022-10
Completion Date
2026-06-24
Last Updated
2022-09-30
Healthy Volunteers
No
Interventions
Biomarker assays
Circulating bone biomarkers assays
Locations (1)
IRCCS Istituto Ortopedico Galeazzi
Milan, Italy