Clinical Research Directory
Browse clinical research sites, groups, and studies.
Micro-UltraSound In Cancer - Active Surveillance
Sponsor: University of Alberta
Summary
This study will compare the two imaging modalities (MRI and micro-ultrasound) during Active Surveillance of prostate cancer (PCa). Progression to clinically significant PCa will be assessed by first taking micro-US targeted samples (while blinded to MRI results), followed by MRI targeted samples, finishing with 12 systematic biopsy cores. The primary goal is to compare microUS to MRI for the detection of ≥GG2 PCa at confirmatory biopsy. This study will also collect blood samples from participants to be used for future biomarker studies.
Official title: Micro-UltraSound In Cancer - Active Surveillance (MUSIC-AS)
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
210
Start Date
2022-11-30
Completion Date
2033-06-30
Last Updated
2025-07-29
Healthy Volunteers
No
Conditions
Interventions
High-resolution micro-ultrasound
In a single biopsy session, first, a microUS-guided biopsy of regions of interest (ROIs) will be performed. The MRI fusion software will then be turned on, the clinician unblinded to the MRI results, and biopsy cores from within the boundaries of the MRI-fused lesion will be sampled from ROIs. Up to two ROIs identified on microUS or MRI will be targeted with up to 3 cores per ROI. If the MRI ROIs overlap with the microUS ROIs after unblinding, then the cores taken during the microUS-guided biopsy will be counted as both microUS and MRI-guided. Finally, a standard 12-core systematic biopsy will be performed.
Locations (5)
University of California Los Angeles, Department of Urology
Los Angeles, California, United States
Kipnes Urology Centre - Kaye Edmonton Clinic
Edmonton, Alberta, Canada
University of British Columbia
Vancouver, Alberta, Canada
CIUSSS du Nord-de-L'Ile-De-Montreal
Montreal, Quebec, Canada
Humanitas
Milan, Italy