Clinical Research Directory

Inclusion Criteria: Case group * Patients must have histologically confirmed colorectal cancer or advanced adenoma. * Patients need to receive surgical resection or endoscopic resection. * Patients have a performance status of ≤1 on the ECOG Performance Scale. * Written informed consent must be obtained. Control group * Written informed consent must be obtained. * Individuals must receive colonoscopy. Exclusion Criteria: * Patients received tumor treatment prior to the drawn of blood sample, including surgical resection, neoadjuvant chemoradiotherapy and targeted therapy. * Patients received antibiotics regularly. * Patients received blood transfusion two weeks before the drawn of blood sample. * Patients with indications of emergency surgery, including bleeding, obstruction and perforation. * Patients who are positive for Human Immunodeficiency Virus (HIV). * Patients with abnormal liver and kidney function. * Patients with the history of other malignancies, inflammatory bowel disease and Lynch syndrome. * Patients who are pregnant or breastfeeding. * Alcoholic or drug abusers.