Clinical Research Directory
Browse clinical research sites, groups, and studies.
Disrupting Fear-based Memory Consolidation
Sponsor: Emory University
Summary
This project represents a unique collaborative opportunity to pursue the essential proof-of-principle demonstration that non-invasive interference of sensory cortical memory consolidation shortly after an emotional experience can attenuate the cued fear response and potentially reduce the risk of developing post-traumatic stress disorder (PTSD). If successful, the study results would anchor a potential advance in the treatment of patients after a traumatic event and seed future animal and clinical studies of emotional sensory cortical memory consolidation to reduce the prevalence and negative sequelae of PTSD.
Official title: Forgetting Fear: Establishing a Novel Non-invasive Approach to Disrupt Fear-based Sensory Memory Consolidation in Humans
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
66
Start Date
2022-11-28
Completion Date
2028-12
Last Updated
2025-10-29
Healthy Volunteers
No
Conditions
Interventions
Continuous theta burst stimulation (cTBS)
cTBS, a patterned form of TMS, (80% active motor threshold intensity, 3 pulses at 50Hz, 200ms interval, 600 pulses, 40s duration applied over the targeted sensory cortical region using real-time neuronavigation to focally and transiently inhibit neural activity
Sham continuous theta burst stimulation (cTBS)
This will be a sham intervention. An active/sham stimulating coil will be used for double-blinding of stimulation condition. cTBS is safe and has established safety guidelines that will be strictly adhered to during study conduction.
Locations (2)
Emory Rehabilitation Hospital
Atlanta, Georgia, United States
Emory University Hospital
Atlanta, Georgia, United States