Clinical Research Directory

Inclusion Criteria: * Overweight and obese individuals with prediabetes and/or impaired glucose tolerance * Age 18 to 70 years * BMI 25-40 kg/m2 * HbA1c between 5.6 - 6.5, Impaired fasting plasma glucose levels (\>99, ≤126 mg/dL) or OGTT blood glucose at 2 hours between 140-200 mg/dL or HOMA-IR \>2.5 * BP \<150/90 with or without medication * GFR\>60 * ALT, AST \<300 * Normal thyroid function is defined as screening TSH within normal ranges, with or without medication Exclusion Criteria: * Use of any medications (except thyroid hormone with normal TSH, anti-hypertensives with blood pressure \<150/90 and non-steroidal rescue inhalers for asthma) * Pregnancy or breastfeeding * Use of over-the-counter (OTC) supplements (except vitamin D). The investigators will ensure that study participants are not using supplements containing fish oil or other lipid supplements (e.g., macadamia oil, krill oil, flaxseed, primrose oil, sea buckthorn oil) within 3 months of study participation * Greater than 3 servings/day combined of cheese, whole-fat milk, kefir, or whole-fat yogurt for the last 3 months before the study. * Diagnosed with any type of diabetes mellitus and/or taking glucose-lowering medications * Recent weight loss (more than 7% of total body weight loss in last 3 months) * Established major chronic diseases such as major cardiovascular disease (history of myocardial infarction, stroke, symptomatic heart failure, coronary artery bypass graft, Atrial fibrillation, symptomatic peripheral arterial disease), bleeding disorder or anticoagulation use, active cancer, end-stage renal disease, proteinuria (\>3g/day), dementia, severe chronic obstructive pulmonary disease (needs systemic steroid therapy), significant liver disease (ALT or AST\>300) * History of ongoing smoking cigarettes \>1 pack/day, alcohol abuse, or illicit drug abuse * Treatment with any investigational drug in the one month preceding the study