Clinical Research Directory

Inclusion Criteria: * Resident of the United States * Females and males ages 25-75 (inclusive) * Able to speak and read English * No unexplained weight loss, fevers, anemia, or blood in stool * Willing and able to follow the trial instructions, as described in the recruitment letter * Signed and dated informed consent prior to any trial-specific procedures. * PHQ9 score of 5-24 (inclusive) Exclusion criteria * Unwilling to change their current diet * Prior use of Viome products or services * Antibiotic use in the previous 4 weeks * Pregnancy (current or planned in the next 4 months) * \< 90 days postpartum * Breast feeding * Active infection * Unable or unwilling to use Viome's App on an iPhone or Android smartphone * Significant diet or lifestyle change in the previous 1 month * IBD diagnosis -Major psychiatric/DSM-4 disease diagnosis (e.g. Schizophrenia, Bipolar disorder, Post- traumatic Stress Disorder, Obsessive Compulsive disorder) * Use of investigational drugs, products or devices within 1 month prior to and 4 months after the start of the trial * Cancer therapy within the previous 1 year * Major surgery in the last 6 months or planned in the next 4 months * Allergies to any supplement ingredients listed in the screening survey * Currently on a specific diet: FODMAP, KETO, PALEO * Answered yes to the question, "In the past few weeks, have you wished you were dead or had thoughts about killing yourself?" * Gastrointestinal disease including: * GI surgery except: * Appendectomy and benign polypectomy * Esophagitis * Celiac disease * GI malignancy or obstruction * Peptic Ulcer Disease * Duodenal or gastric ulcer disease