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Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation
Sponsor: Region Skane
Summary
The STEPCARE-trial is a 2x2x2 randomised trial studying patients who have been resuscitated from cardiac arrest and who are comatose. It will include three different interventions focusing on sedation targets, temperature targets and mean arterial pressure targets.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3500
Start Date
2023-08-17
Completion Date
2026-12
Last Updated
2025-07-15
Healthy Volunteers
No
Interventions
Feedback-controlled temperature device
If core body temperature exceeds 37.7°C a feedback controlled-device will be used and set at 37.5°C.
High MAP
A MAP target of \>85mmHg will be used. Vasopressors will be titrated to this target during 36h.
Deep sedation
Deep sedation for at least 36h
Fever control without a device
Management of fever in the ICU without a device
Low MAP
A MAP target of \>65mmHg will be used. Vasopressors will be titrated to this target during 36h.
Minimal sedation
A strategy of minimal sedation in the ICU, used only as needed to facilitate transport, imaging and invasive procedures.
Locations (56)
Nepean Hospital
Kingswood, New South Wales, Australia
Liverpool Hospital
Liverpool, New South Wales, Australia
Royal North Shore Hospital
Sydney, New South Wales, Australia
St George Hospital
Sydney, New South Wales, Australia
The Sutherland Hospital
Sydney, New South Wales, Australia
Princess Alexandra Hospital
Brisbane, Queensland, Australia
The Prince Charles Hospital
Brisbane, Queensland, Australia
Austin Hospital
Melbourne, Victoria, Australia
HUB Hôpital Erasme
Brussels, Belgium
Ghent University Hospital
Ghent, Belgium
Ziekenhuis Oost-Limburg Hospital
Lanaken, Belgium
North Estonia Medical Centre, Tallinn
Tallinn, Estonia
Jorvi Hospital
Espoo, Finland
Meilahti Hospital
Helsinki, Finland
Helsinki Helsingforgs University Central Hospital
Helsinki, Finland
Jyväskylä Hospital
Jyväskylä, Finland
Kuopio University Hospital
Kuopio, Finland
Oulu University Hospital
Oulu, Finland
Tampere University Hospital
Tampere, Finland
Charite University Hospital
Berlin, Germany
Lübeck University Hospital
Lübeck, Germany
Tubingen University Hospital
Tübingen, Germany
St Vincents University Hospital
Dublin, Ireland
San Martino Hospital Genova
Genova, Italy
Centre Hospitalier de Luxembourg
Luxembourg, Luxembourg
DCCM ICU
Auckland, New Zealand
Middlemore ICU
Auckland, New Zealand
North Shore ICU NZ
Auckland, New Zealand
Christchurch Hospital
Christchurch, New Zealand
Whangarei ICU
Northland, New Zealand
Wellington Hospital
Wellington, New Zealand
Soerlandet Hospital Arendal
Arendal, Norway
Kalnes Hospital
Kalnes, Norway
Oslo University Hospital
Oslo, Norway
Stavanger University Hospital
Stavanger, Norway
King Abdulaziz Medical City
Riyadh, Saudi Arabia
Tan Tock Seng Hospital
Singapore, Singapore
Hallands hospital
Halmstad, Halland County, Sweden
Helsingborg Hospital
Helsingborg, Skåne County, Sweden
Skåne University Hospital
Lund, Skåne County, Sweden
Skåne University Hospital Malmö
Malmo, Skåne County, Sweden
Sahlgrenska University Hospital
Gothenburg, Sweden
Karlstad hospital
Karlstad, Sweden
Skaraborg Hospital Skovde
Skövde, Sweden
Karolinska University Hospital
Stockholm, Sweden
University Hospital of Umeå
Umeå, Sweden
Bern University Hospital
Bern, Switzerland
St Gallen Hospital
Sankt Gallen, Switzerland
University Hospital Zürich
Zurich, Switzerland
Essex Cardiothoracic Centre
Basildon, United Kingdom
Bristol Royal Infirmary
Bristol, United Kingdom
Cardiff University Hospital
Cardiff, United Kingdom
Leeds General Infirmary
Leeds, United Kingdom
Kings College Hospital
London, United Kingdom
St Bartholomew's Hospital
London, United Kingdom
St Georges University Hospital
London, United Kingdom