Clinical Research Directory

Inclusion Criteria: * Stage 1 hypertension (blood pressure is in 130-139/80-89 mmHg); * 35 - 64 years old * Without taking antihypertensive medicine during screening * Signed the written informed consent Exclusion Criteria: * took antihypertensive medicine within the last 1 month; * History of large atherosclerotic cerebral infarction or hemorrhagic stroke (not lacunar infarction and transient ischemic attack \[TIA\]); * History of myocardial infarction or unstable angina or history of coronary revascularization (PCI or CABG); * Lab tests indicating abnormal liver or kidney function (ALT ≥ 3 times the upper limit of normal value, or estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m2); * History of sustained atrial fibrillation or Ventricular arrhythmias at entry influencing the measurement of electronic blood pressure； * Severe valvular disease or valvular disease likely to require surgery or percutaneous valve replacement during the trial; * Dilated or hypertrophic cardiomyopathy, rheumatic heart disease, or congenital heart disease; * Severe somatic disease such as cancer; * Severe cognitive impairment or mental disorders; * pregnant or breastfeeding, or planning to be pregnant; * having organ transplantation; * Participating in other clinical trials.