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PROFAST Intervention in Precursor Multiple Myeloma
Sponsor: Dana-Farber Cancer Institute
Summary
This is a 4-month randomized trial of a prolonged nightly fasting intervention (PROFAST) in 40 overweight and obese individuals with monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), and smoldering waldenstrom macroglobulinemia (SWM). The purpose of this study is to understand if fasting for a prolonged period of time during the nighttime hours is a strategy to prevent overweight and obese individuals from developing blood cancer. Participants will be randomized into the following two groups: * Group A: PROFAST intervention for 4 months * Group B: Healthy Lifestyle Control group for 4 months
Official title: PROlonged Nightly FASTing for Obesity Reduction and Prevention of Disease Prevention in Precursor Multiple Myeloma (PROFAST)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
23
Start Date
2023-03-06
Completion Date
2025-08-04
Last Updated
2026-10-07
Healthy Volunteers
No
Conditions
Interventions
Prolonged Fasting Intervention
promote a 14-hour fast during the nighttime hours
EDUCATION CONTROL
introductory session with a health coach and educational information will be provided. Participants will also receive one email and one text message per week with tips on healthy living
Locations (1)
Dana Farber Cancer Institute
Boston, Massachusetts, United States