Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
SUSPENDED
NCT05567848
PHASE1/PHASE2

Accelerated TMS in Psychosis

Sponsor: Beth Israel Deaconess Medical Center

View on ClinicalTrials.gov

Summary

This study is to determine the tolerability and efficacy of an accelerated schedule of Transcranial Magnetic Stimulation for treating symptoms of psychotic disorders such as schizophrenia.

Official title: Accelerated Transcranial Magnetic Stimulation in Psychotic Disorders

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

20

Start Date

2022-11-29

Completion Date

2027-01

Last Updated

2026-04-22

Healthy Volunteers

No

Interventions

DEVICE

repetitive Transcranial Magnetic Stimulation (rTMS)

rTMS is a technique of TMS that allows the selective external manipulation of neural activity in a non-invasive manner. During TMS, a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field that in turn induces electrical current in neurons and allows the modulation of neural circuitry. The combination of TMS with functional MRI allows the selective targeting and modulation of brain networks. The repeated application of rTMS can cause long term changes in behavior and task performance that is reflected in altered brain network connectivity. The pattern of rTMS will consist of intermittent Theta Burst Stimulation (iTBS) pattern consisting of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz, every 10s for a total of 600 pulses per session. Sessions will be separated by an interval of 50 minutes (up to a total of 8 per day).

Locations (1)

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States