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RECRUITING
NCT05568680
PHASE1

SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or Mesothelioma

Sponsor: Verismo Therapeutics

View on ClinicalTrials.gov

Summary

This first-in-human (FIH) trial is designed to assess the safety, feasibility, and potential activity of a single intravenous (IV) dose of SynKIR-110 administered to subjects with mesothelin-expressing advanced ovarian cancer, mesothelioma, and cholangiocarcinoma.

Official title: A Phase 1 Study of SynKIR-110, Autologous T Cells Transduced With Mesothelin KIR-CAR, in Subjects With Mesothelin-Expressing Advanced Ovarian Cancer, Cholangiocarcinoma, or Mesothelioma

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

42

Start Date

2023-03-30

Completion Date

2027-12

Last Updated

2026-02-10

Healthy Volunteers

No

Interventions

BIOLOGICAL

SynKIR-110, Autologous T cells Transduced with Mesothelin KIR-CAR

Autologous T cells Transduced with Mesothelin KIR-CAR

Locations (4)

University of Kansas Cancer Center

Westwood, Kansas, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

MD Anderson Cancer Center

Houston, Texas, United States

University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, United States