Clinical Research Directory

Inclusion Criteria: * Patients with moderate-to-severe plaque psoriasis. Standard criteria for moderate-to-severe plaque psoriasis will be used (BSA greater than or equal to 3% or face/palm/sole/genital involvement or severe effect on Quality of Life). * Subject must be 18 years of age or older. * Subject must have a working knowledge of English. * Approved birth control methods required for females of childbearing potential. * Baseline TB test. Exclusion Criteria: * Patients without a diagnosis of moderate-to-severe plaque psoriasis. * Patients under 18 years of age. * Patients with severe or unstable comorbid conditions. * Patients with active malignancy or malignancy in past 5 years (not including appropriately treated cutaneous basal and cutaneous-limited squamous cell carcinomas). * Patients who are pregnant or breastfeeding. * Patients with any other skin condition that prohibit or confound the ability of the investigator to interpret skin findings. * Patients with active substance or alcohol abuse disorder; or history of substance/alcohol abuse disorder within 6 months prior to study enrollment. * History of, or active, severe depression and/or suicidality. * Patients with active or latent tuberculosis as determined by quant-TB baseline testing * Patients that are taking concomitant biologics, systemics for the treatment of psoriasis and/or phototherapy.