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Study of the Impact of Mother-of-pearl Nutritional Supplementation on the Prevention of Post-menopausal Osteoporosis
Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Summary
Post-menopausal osteoporosis and the resulting fractures are an important cause of disability and loss of independence. They also increase the risk of morbidity and mortality. Given potential side effects, hormone replacement therapy is no longer recommended for menopausal women with risk of becoming osteoporotic. The very significant decrease in the use of these treatments is suspected of contributing to a resurgence in the incidence of osteoporotic fractures, particularly in women before the age of 70. There is a need for prevention of osteoporosis.
Official title: Study of the Impact of Mother-of-pearl Nutritional Supplementation on the Prevention of Post-menopausal Osteoporosis: Multicentre, Double-blind Randomized Versus Positive Comparator Study
Key Details
Gender
FEMALE
Age Range
50 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2023-05-12
Completion Date
2028-11
Last Updated
2025-06-19
Healthy Volunteers
No
Conditions
Interventions
Mother-of-pearl
The mother-of-pearl, derived from the inner shell of marine molluscs, is composed of calcium carbonate and organic compounds, some of which peptides are active on the bone. The mineralization inducing activity of the molecules extracted from the mother-of-pearl has been shown in vitro. Mother-of-pearl extract also contains molecules that inhibit the resorption activity of osteoclasts. Mother-of-pearl compounds can thus slow bone remodelling as showed in an ovariectomy-induced osteoporosis model in rat, where mother-of-pearl supplementation showed a better effect on limitation of bone loss than calcium carbonate supplementation.
Calcium Carbonate
Calcium carbonate is a source of calcium.
Locations (7)
Hôpital Gabriel Montpied
Clermont-Ferrand, France
Clinique Universitaire de Rhumatologie
Grenoble, France
CH Emile Roux
Le Puy-en-Velay, France
Hôpital Edouard Herriot
Lyon, France
APHP - Hôpital Cochin
Paris, France
CH Roanne
Roanne, France
CHU Saint-Etienne
Saint-Etienne, France