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NOAC9 - Circulating Tumor DNA Guided Follow-Up in Anal Cancer
Sponsor: Aarhus University Hospital
Summary
This study investigates if circulating tumor DNA can improve the detection of early treatment failure or recurrence in localized squamous cell carcinoma of the anus (SCCA) after curative chemoradiotherapy thereby increasing the potential for cure. This will be done by comparing the standard follow-up program with ctDNA guided imaging follow-up. Secondly, the aim is to establish early interventions against late morbidities.
Official title: NOAC9 - A Phase II Randomised Nordic Anal Cancer Group Study on Circulating Tumor DNA Guided Follow-Up
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2023-08-02
Completion Date
2031-06-01
Last Updated
2024-08-14
Healthy Volunteers
No
Conditions
Interventions
AMR B: HPV positive ctDNA guided imaging in follow-up
Blood samples in follow-up positive for ctDNA leads to an extra PET-CT scan to detect early treatment failure
Locations (13)
Department of Oncology Herlev and Gentofte Hospital
Herlev, Capital Region of Denmark, Denmark
Department of Oncology, Vejle Hospital
Vejle, The Regions of Southern Denmark, Denmark
Aarhus University Hospital
Aarhus, Denmark
Tampere University Hospital
Tampere, Finland
Turku University Hospital
Turku, Finland
Haukeland University Hospital
Bergen, Norway
Oslo University Hospital
Oslo, Norway
University Hospital of North Norway
Tromsø, Norway
St. Olav's University Hospital
Trondheim, Norway
Sahlgrenska University Hospital
Gothenburg, Sweden
Skåne University Hospital Lund
Lund, Sweden
Karonlinska University Hospital
Stockholm, Sweden
Norrlands University Hospital
Umeå, Sweden