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A Pilot Study for Optimizing Meropenem Administration in the ICU
Sponsor: Oslo University Hospital
Summary
Can antibiotic drugs be administered faster and make acceptable serum concentrations if we give short but multiple infusions compared to long and fewer infusions? In this study we will compare giving meropenem 1 gram 6 times daily in 15 minutes infusions to the recommended 2 gram 3 times daily in 3 hours infusions. In patients in the intensive care unit, the need for intravenous access is of essence. If 6 short infusions results in the same serum concentrations as 3 long infusions, we will increase intravenous access from 15 to 22.5 hours daily.
Official title: A Pilot Study for Optimizing Meropenem Administration in the Intensive Care Unit - Short Six Times vs Prolonged Three Times Courses Daily
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2021-12-14
Completion Date
2027-06
Last Updated
2025-04-24
Healthy Volunteers
No
Conditions
Interventions
Meropenem 1000 mg
given as 6 or 3 infusions in 15 minues or 3 hours.
Locations (1)
Oslo University Hospital
Oslo, Norway