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V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)
Sponsor: University Hospital, Angers
Summary
This study aim to compare the effect of Positive End Expiratory Pressure (PEEP) on ventilation/perfusion mismatch in two phenotypes of patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), characterized by their respiratory system elastance (Ers). Ventilation/perfusion mismatch will be assessed by Electrical Impedance Tomography (EIT).
Official title: Effect of PEEP on Ventilartion/Perfusion Ratios According to Different Phenotypes in Patients With ARDS (France)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-02-08
Completion Date
2026-09
Last Updated
2025-12-08
Healthy Volunteers
No
Conditions
Interventions
PEEP increase
Positive End Expiratory Pressure (PEEP) will be increased from 5 to 15 cmH2O.
PEEP decrease
Positive End Expiratory Pressure (PEEP) will be decreased from 15 to 5 cmH2O.
Locations (1)
Angers Hospital
Angers, Maine et Loire, France