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Xylitol BSI Multisite - Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant
Sponsor: Children's Hospital Medical Center, Cincinnati
Summary
Bloodstream infections (BSI) caused by bacteria translocating across injured oral mucosa are a significant cause of morbidity and mortality in patients undergoing stem cell transplantation (SCT). Unfortunately, there are currently no known strategies to prevent these BSI in this vulnerable population. The investigators will conduct a randomized, double-blind, placebo-controlled trial at three institutions to evaluate the effectiveness of twice daily intraoral xylitol-wipe application on reducing BSI in pediatric SCT patients.
Official title: Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant: a Randomized, Multicenter, Double-blind , Placebo-controlled Study Evaluating Twice Daily Oral Xylitol
Key Details
Gender
All
Age Range
4 Months - 25 Years
Study Type
INTERVENTIONAL
Enrollment
419
Start Date
2023-04-04
Completion Date
2027-06-30
Last Updated
2026-04-07
Healthy Volunteers
No
Conditions
Interventions
Xylitol
Xylitol wipes
Placebo
Placebo wipes
Locations (3)
Children's Hospital Colorado
Aurora, Colorado, United States
Dana-Farber/Boston Children's
Boston, Massachusetts, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States