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A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
Sponsor: Genentech, Inc.
Summary
This is a first-in-human study to evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of RO7502175 when administered as a single agent and in combination with atezolizumab or pembrolizumab in adult participants with locally advanced or metastatic solid tumors, including non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), melanoma, triple-negative breast cancer (TNBC), esophageal cancer, gastric cancer, cervical cancer, colorectal cancer (CRC), urothelial carcinoma (UC), clear cell renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). Participants will be enrolled in 2 stages: dose escalation and dose expansion.
Official title: A Phase Ia/Ib, Open Label, Multicenter, Dose-escalation Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
450
Start Date
2022-10-20
Completion Date
2027-02-28
Last Updated
2026-02-17
Healthy Volunteers
No
Conditions
Interventions
RO7502175
RO7502175 will be administered as per the schedules specified in the respective arms.
Atezolizumab
Atezolizumab will be administered as per the schedules specified in the respective arms.
Pembrolizumab
Pembrolizumab will be administered as per the schedules specified in the respective arms.
Locations (41)
Stanford University
San Francisco, California, United States
University Of Colorado
Aurora, Colorado, United States
Florida Cancer Specialists - Sarasota
Sarasota, Florida, United States
Winship Cancer Institute
Atlanta, Georgia, United States
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Henry Ford Hospital
Detroit, Michigan, United States
Washington University Medical Center, Division of Oncology
St Louis, Missouri, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
The West Clinic - Memphis (Union Ave)
Germantown, Tennessee, United States
SCRI Oncology Partners
Nashville, Tennessee, United States
South Texas Accelerated Research Therapeutics (START)
San Antonio, Texas, United States
Kinghorn Cancer Centre
Darlinghurst, New South Wales, Australia
Monash Health Monash Medical Centre
Clayton, Victoria, Australia
Linear Clinical Research Ltd
Nedlands, Western Australia, Australia
UZ Antwerpen
Edegem, Belgium
CHU de Liège
Herstal, Belgium
GasthuisZusters Antwerpen
Wilrijk, Belgium
British Columbia Cancer Agency
Vancouver, British Columbia, Canada
Ottawa Hospital Regional Cancer Centre
Ottawa, Ontario, Canada
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Sir Mortimer B Davis Jewish General Hospital
Montreal, Quebec, Canada
University General Hospital ''ATTIKON'' - General Hospital of West Attica H AGIA VARVARA
Chaïdári, Attica, Greece
Papageorgiou General Hospital of Thessaloniki
Pavlos Melas, Thessaloniki, Greece
Sotiria Thoracic Diseases Hospital of Athens
Athens, Greece
Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis
Amsterdam, Netherlands
Universitair Medisch Centrum Groningen
Groningen, Netherlands
Seoul National University Hospital
Seoul, South Korea
Asan Medical Center - PPDS
Seoul, South Korea
Samsung Medical Center - PPDS
Seoul, South Korea
Severance Hospital Yonsei University Health System - Clinical Trials Center Pharmacy
Seoul, South Korea
ICO Hospitalet- Hospital Duran i Reynals
L'Hospitalet de Llobregat, Barcelona, Spain
Instituto de Investigacion Oncologica Vall dHebron (VHIO) - EPON
Barcelona, Spain
START MADRID_Hospital Universiario Fundacion Jimenez Diaz
Madrid, Spain
Hospital Universitario 12 De Octubre
Madrid, Spain
Hospital Universitario Virgen de la Victoria
Málaga, Spain
Hospital Clinico Universitario de Valencia
Valencia, Spain
Sahlgrenska Universitetssjukhuset
Gothenburg, Sweden
Karolinska Universitetssjukhuset Solna
Stokholm, Solna, Sweden
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
Chung Shan Medical University Hospital
Taichung, Taiwan
National Taiwan University Hospital
Taipei, Taiwan