Clinical Research Directory

Inclusion Criteria: Inclusion of the index cases * Age ≥18 years * Newly bacteriologically confirmed TB case (within 1 month of diagnosis) * Living in the same household for the last 3 months * Reporting at least one HH contact * Providing written informed consent for participation in the study Inclusion of contacts * All contacts living in the same HH, defined as any person who shared the same enclosed living space as the index TB case for one or more nights or for frequent or extended daytime periods for at least one month before the TB diagnosis is made. * Providing written informed consent (signed by adult (≥18 years) contacts; or by parents/guardians for minors \< 13 years or incapacitated people; written assent for children ≥13 years and \< 18 years). Exclusion Criteria: Exclusion of index cases * Index case who do not live in the catchment area of the study cluster * Index cases diagnosed with rifampicin resistance, multidrug resistance (MDR) or extensively drug-resistant (XDR-TB) * Index cases who are incarcerated Exclusion of the contacts \- contact currently on TPT or on TB treatment or who finished such treatment in the last 3 months.