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Treatment of Meniere's Disease With Migraine Medications
Sponsor: University of California, Irvine
Summary
Meniere's disease (MD) is a chronic disease with a variety of fluctuating signs and symptoms, which include vertigo, hearing loss, tinnitus (ringing noise in the ear), aural pressure (feeling of ear fullness), and disequilibrium (lack of stability). Vertigo represents one of the most common and distressing problems in MD patients, and it causes various somatic and psychological disorders that interfere with the patient's quality of life. Despite the large economic and emotional impact of symptoms in MD patients, there is no FDA-approved medication to treat this debilitating condition. As such, our objective in this study is to evaluate the therapeutic potential of novel medications in treating MD that have previously shown astonishing promise in our clinical practice.
Official title: Treatment of Meniere's Disease With Nortriptyline-Topiramate Stepwise Regimen: A Randomized Double-Blinded Clinical Trial
Key Details
Gender
All
Age Range
25 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2022-08-01
Completion Date
2026-12-30
Last Updated
2024-08-09
Healthy Volunteers
No
Conditions
Interventions
nortriptyline + topiramate
nortriptyline (7.5mg) + topiramate (10mg) taken 1x per day and escalate weekly as needed for 8 weeks
Locations (1)
University of California, Irvine Medical Center ENT Clinic (Pavilion 2)
Orange, California, United States