Clinical Research Directory

Inclusion Criteria: Group 1. Patients with diagnosis or high probability of medium and high prostate cancer according International Society of Urological Pathology (ISUP) risk for whom radical treatment is planned * Prostate adenocarcinoma confirmed by biopsy and histopathological examination * Results indicating a moderate RGK (Gleason score 7 or cT2b or PSA 10-20 ng / ml) or high (Gleason score\> 7 or cT2c or PSA\> 20 ng / ml) risk according to ISUP * Creatinine value allowing for safe PET / MR examination with a contrast agent: creatinine less than or equal to 1.5 times the upper limit of normal, creatinine clearance\> 60 mL / min * Age ≥18 years * Signing informed consent to participate in the study * Pelvic / prostate mpMR examination performed, not earlier than 30 days before inclusion in the study Group 2. Patients with RGK after radical treatment, with biochemical recurrence according to EAU criteria, who are scheduled for further treatment and the result of the imaging / molecular examination may affect change of therapeutic decision: * Prostate adenocarcinoma confirmed by biopsy and histopathological examination * After radical treatment * In patients after radical prostatectomy: with at least two PSA measurements ≥0.2 ng / ml not earlier than after 6-13 weeks after radical prostatectomy or PSA≥0.1 with PSAdt (PSA doubling time) \<3 months PSA on at least two consecutive studies in consecutive last 6 months before qualification (last determination within 6 weeks before qualification) Or * In patients after radical radiotherapy: biochemical recurrence defined as nadir PSA + 2 ng / ml * Age ≥18 years * Signing informed consent Exclusion Criteria: * Presence of metallic foreign bodies / implants / prostheses / stimulators etc. inside the body, the possession of which is a contraindication to the MR 3T examination * Claustrophobia * Patient size precluding PET / MR examination due to diameter gantry * Known contraindications for the use of radiopharmaceuticals or substances auxiliary (e.g. renal failure and allergy to ingredients in the preparation) * Treatment for malignant neoplasm not associated with the prostate gland * Participating in another clinical trial * Lack of informed consent to participate in the study * Age \<18 years