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Medical Treatment Versus Surgery in Stricturing Small Bowel Crohn's Disease
Sponsor: Nantes University Hospital
Summary
The objective of the SMART trial is to compare a combination therapy using azathioprine and subcutaneous infliximab versus ileocecal resection in patients with symptomatic small bowel Crohn's disease.
Official title: SyMptomAtic Stricturing Small Bowel CRohn's Disease - Medical Treatment Versus Surgery, a Prospective, Multi-centre, Randomized, Non-inferiority Trial
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2023-04-01
Completion Date
2027-10-01
Last Updated
2022-10-18
Healthy Volunteers
No
Conditions
Interventions
Azathioprine + infliximab
Combination therapy using 2-2.5 mg/kg oral azathioprine plus subcutaneous infliximab
Intestinal resection
Ileocolonic or small bowel resection