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Decolonization to Reduce After-Surgery Events of Surgical Site Infection
Sponsor: University of California, Irvine
Summary
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2700
Start Date
2023-01-17
Completion Date
2028-12
Last Updated
2025-07-28
Healthy Volunteers
No
Conditions
Interventions
4% Chlorhexidine Gluconate
Used for daily showering/bathing for 30 days after hospital discharge.
2% Mupirocin
Applied to each nostril twice daily for five days for the first two weeks after hospital discharge.
Soap Without Antiseptic Properties (Placebo)
Used for daily showering/bathing for 30 days after hospital discharge.
Placebo Nasal Ointment
Applied to each nostril twice daily for five days for the first two weeks after hospital discharge.
Locations (4)
Hoag Memorial Hospital Presbyterian
Newport Beach, California, United States
University of California, Irvine Medical Center
Orange, California, United States
University of California, Davis Medical Center
Sacramento, California, United States
University of California, San Francisco Medical Center
San Francisco, California, United States