Clinical Research Directory

Inclusion Criteria: * SLE fulfilling 2019 ACR/EULAR or 2012 SLICC criteria * willing to perform DXA/ x-Ray investigation (common clinical practice) * willing to donate blood sample * willing to complete questionnaires * the patients should be in a stable disease activity. Exclusion Criteria: * Uncontrolled endocrinological disease. * metabolic bone disease other than osteoporosis ( e.g. Paget disease). * celiac disease, inflammatory bowel disease or pancreatic exocrine deficiency resulting in malabsorption * patients lacking medication history information (SLE and bone related medications). * Have any other clinically significant abnormal laboratory value in the opinion of the investigator * Have any intercurrent significant medical illness that the investigator considers would make the candidate unsuitable for the study. * The patients shouldn't be enrolled during a moderate to severe flare of disease requiring an escalation of therapy ( especially glucocorticoid) - no new BILAG A or B in the last 3 months. * Pregnant patients or during the first year after child birth.