Clinical Research Directory
Browse clinical research sites, groups, and studies.
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
Sponsor: Medical College of Wisconsin
Summary
The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autophagy and subsequently microvascular function? Participants will undergo 2 study days. The primary outcome will be in vivo microvascular function testing. Following the first study day participants will undergo either supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second study day will test in vivo microvascular function.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-01-01
Completion Date
2029-12-31
Last Updated
2025-10-30
Healthy Volunteers
Yes
Conditions
Interventions
Trehalose
Trehalose will be given at a dose of 10g mixed in 500 mL of water to be consumed 1 time per day for 14 days
Placebo
Microcrystalline cellulose will be given at a dose of 10g mixed in 500 mL of water to be consumed 1 time per day for 14 days
Locations (1)
Medical College of Wisconsin
Milwaukee, Wisconsin, United States