Clinical Research Directory

Inclusion Criteria: * The patient's age is over 18 at the time of surgery. * The patient suffers from Crohn's disease confirmed by instrumental and histological methods. * The patient presents with complex perianal fistulising disease refractory to standard treatment (combination of surgical drainage of sepsis and local / systemic administration of anti-TNF-α for at least 1 year) * The patient received, understood and signed informed consent for active participation in the study. * The patient is able to understand the conditions of the study and to participate throughout the duration. Exclusion Criteria: * Patients with more than 1 internal and 3 external openings. * Patients with ileus / colo ostomy. * Patients with anus / rectum-vaginal fistulas. * Patients with active HIV infections, hepatitis C (HCV), hepatitis B (HBV), tuberculosis. * Patients with abdominal localization of Crohn's disease who may require general surgery during the study. * Patients with active oncological or lymphoproliferative diseases from which it was not possible to safely withdraw an adequate quantity of lipoaspirate (at least 60 cc). * Patients with clinical conditions that may compromise the success of the surgery or the follow-up. * Pregnant or breastfeeding women.