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Circulating and Urine Tumor DNA Dynamics Predict Minimal Residual Disease and Recurrence Risk in Locally Advanced Upper Tract Urothelial Carcinoma
Sponsor: RenJi Hospital
Summary
In our study, the ultra-deep sequencing of circulating tumor DNA (ctDNA) and urine tumor DNA (utDNA) were performed to assess whether ctDNA and utDNA can be used as predictive biomarkers for the detection of minimal residual disease (MRD) and early diagnosis of UTUC recurrence, and explored the role of ctDNA and utDNA detection of MRD in the prediction of adjuvant therapy efficacy and prognostic evaluation.
Official title: Circulating and Urine Tumor DNA Dynamics Predict Minimal Residual Disease and Recurrence Risk in Locally Advanced Upper Tract Urothelial Carcinoma(CURATE-UTUC): A Multicenter Prospective Longitudinal Cohort Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
84
Start Date
2022-02-01
Completion Date
2026-12-31
Last Updated
2025-12-09
Healthy Volunteers
No
Interventions
Adjuvant chemotherapy
cisplatin/carboplatin-gemcitabine 4-6 cycles
adjuvant immunotherapy
immunotherapy for one year
Locations (1)
Renji Hospital
Shanghai, Shanghai Municipality, China