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Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women
Sponsor: Queen Mary University of London
Summary
Important differences exist between sexes in incidence, disease patterns and outcomes in coronary artery disease that is not well understood. It is likely that key differences in the underlying biological mechanism, in particular in inflammatory responses, play a part in underpinning these differences. Previous evidence demonstrates that healthy females appear to be more adept at resolving inflammation compared to healthy males. Since inflammation is thought to be a key initiating phenomenon in coronary artery disease the investigators will examine the differences in inflammatory resolution between the sexes in healthy volunteers.
Official title: Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women: RESOLVE-SEX
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
34
Start Date
2022-12-12
Completion Date
2027-12-12
Last Updated
2026-01-07
Healthy Volunteers
Yes
Conditions
Interventions
Cantharidin
0.1% cantharidin solution in acetone from 0.7% stock solution of cantharone is prepared and applied immediately. 10 μl of cantharidin per disc.
Locations (1)
The William Harvey Research Institute
London, United Kingdom