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A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
Sponsor: Bellus Health Inc. - a GSK company
Summary
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC).
Official title: A Phase 3, 52-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Efficacy and Safety Study With Open-Label Extension of BLU-5937 in Adult Participants With Refractory Chronic Cough, Including Unexplained Chronic Cough (CALM-1)
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
825
Start Date
2022-10-25
Completion Date
2026-05-28
Last Updated
2025-06-10
Healthy Volunteers
No
Conditions
Interventions
BLU-5937
Oral administration of BLU-5937 Tablets
Placebo
Oral administration of matching placebo for BLU-5937 Tablets
Locations (191)
GSK Investigational Site
Litchfield Park, Arizona, United States
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Scottsdale, Arizona, United States
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Encinitas, California, United States
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Mission Viejo, California, United States
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Paramount, California, United States
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Roseville, California, United States
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Aurora, Colorado, United States
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Colorado Springs, Colorado, United States
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Clearwater, Florida, United States
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Gainesville, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Miami, Florida, United States
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Orlando, Florida, United States
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Lawrenceville, Georgia, United States
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Normal, Illinois, United States
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Oak Lawn, Illinois, United States
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Ames, Iowa, United States
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Iowa City, Iowa, United States
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Kansas City, Kansas, United States
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Topeka, Kansas, United States
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Wichita, Kansas, United States
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Crowley, Louisiana, United States
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Shreveport, Louisiana, United States
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Annapolis, Maryland, United States
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North Dartmouth, Massachusetts, United States
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Ann Arbor, Michigan, United States
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Ypsilanti, Michigan, United States
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Columbia, Missouri, United States
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St Louis, Missouri, United States
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St Louis, Missouri, United States
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Missoula, Montana, United States
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Jersey City, New Jersey, United States
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The Bronx, New York, United States
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Charlotte, North Carolina, United States
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Raleigh, North Carolina, United States
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Rocky Mount, North Carolina, United States
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Salisbury, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Columbus, Ohio, United States
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Dayton, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Tulsa, Oklahoma, United States
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Medford, Oregon, United States
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Portland, Oregon, United States
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Philadelphia, Pennsylvania, United States
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Warwick, Rhode Island, United States
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Charleston, South Carolina, United States
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Little River, South Carolina, United States
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Mt. Pleasant, South Carolina, United States
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Rock Hill, South Carolina, United States
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Bristol, Tennessee, United States
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Knoxville, Tennessee, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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McKinney, Texas, United States
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San Antonio, Texas, United States
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Waco, Texas, United States
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Salt Lake City, Utah, United States
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Norfolk, Virginia, United States
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Williamsburg, Virginia, United States
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Bellevue, Washington, United States
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Bellingham, Washington, United States
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Ciudad Autonoma Buenos Aires, Argentina
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Ciudad Autonoma de Buenos Aire, Argentina
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Córdoba, Argentina
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Mar del Plata, Argentina
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Mendoza, Argentina
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Rosario, Argentina
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Rosario, Argentina
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Rosario, Argentina
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San Miguel de Tucumán, Argentina
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Santa Fe, Argentina
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Vicente López, Argentina
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Brussels, Belgium
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Ghent, Belgium
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Kortrijk, Belgium
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Leuven, Belgium
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Liège, Belgium
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Mechelen, Belgium
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Roeselare, Belgium
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Calgary, Alberta, Canada
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Calgary, Alberta, Canada
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Kelowna, British Columbia, Canada
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Ajax, Ontario, Canada
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Hamilton, Ontario, Canada
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Hamilton, Ontario, Canada
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Toronto, Ontario, Canada
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Windsor, Ontario, Canada
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Greenfield Park, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Québec, Quebec, Canada
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Québec, Quebec, Canada
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Québec, Quebec, Canada
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Québec, Quebec, Canada
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Saint-Charles-Borromée, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Trois-Rivières, Quebec, Canada
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Victoriaville, Quebec, Canada
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Burlington, Canada
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Floridablanca, Colombia
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Medellín, Colombia
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Medellín, Colombia
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Medellín, Colombia
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Dijon, France
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Lille, France
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Marseille, France
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Marseille, France
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Montpellier, France
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Paris, France
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Strasbourg, France
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Toulouse, France
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Balatonfüred, Hungary
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Budapest, Hungary
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Budapest, Hungary
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Gödöllő, Hungary
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Hajdúnánás, Hungary
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Mosonmagyaróvár, Hungary
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Pécs, Hungary
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Püspökladány, Hungary
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Aurangabad, India
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Bengaluru, India
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Delhi, India
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Jaipur, India
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Kolkata, India
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Kozhikode, India
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Nashik, India
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Nashik, India
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Pune, India
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Rohtak, India
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Thane, India
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Ulhasnagar, India
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Hadera, Israel
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Haifa, Israel
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Jerusalem, Israel
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Petah Tikva, Israel
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Ramat Gan, Israel
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Tel Aviv, Israel
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Alkmaar, Netherlands
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Arnhem, Netherlands
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Breda, Netherlands
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Eindhoven, Netherlands
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Uden, Netherlands
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Zutphen, Netherlands
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Zwolle, Netherlands
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Bialystok, Poland
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Bydgoszcz, Poland
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Bydgoszcz, Poland
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Lodz, Poland
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Lodz, Poland
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Ostrowiec Świętokrzyski, Poland
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Piaseczno, Poland
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Rzeszów, Poland
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Tarnów, Poland
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Zawadzkie, Poland
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Bloemfontein, South Africa
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Durban, South Africa
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Durban, South Africa
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George, South Africa
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Johannesburg, South Africa
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Johannesburg, South Africa
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Pretoria, South Africa
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Somerset West, South Africa
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Alcobendas, Spain
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Badalona, Spain
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Barcelona, Spain
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Barcelona, Spain
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Barcelona, Spain
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Granada, Spain
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Madrid, Spain
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Madrid, Spain
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Málaga, Spain
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Málaga, Spain
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Pamplona, Spain
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Pozuelo de Alarcón, Spain
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Santiago de Compostela, Spain
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Belfast, United Kingdom
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Bristol, United Kingdom
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Corby, United Kingdom
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Hayle, United Kingdom
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Hull, United Kingdom
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London, United Kingdom
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Northwood, United Kingdom
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Orpington, United Kingdom
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Shipley, United Kingdom
GSK Investigational Site
Wythenshawe, United Kingdom