Clinical Research Directory

Inclusion Criteria: 1. Aged 18-75 years; 2. ECOG score 0-2; 3. Rectal adenocarcinoma confirmed by pathology; 4. The lower margin of the tumor was less than 12cm from the anal margin; 5. Patients with clinical stage cT3-4N0M0 or cTanyN+M0; 6. Newly treated patients who have not received treatment including radiotherapy, chemotherapy and surgery; 7. Liver, kidney and other organs have good function and can tolerate radiotherapy, chemotherapy and surgery; 8. Patients and family members can understand the study protocol, voluntarily participate in the study and sign informed consent. Exclusion Criteria: 1. ECOG score \> 2; 2. Patients with multiple primary colorectal cancers; 3. A history of other malignant tumors (other than cured basal cell carcinoma, cervical carcinoma in situ, surgically treated localized prostate cancer, or surgically resected breast ductal carcinoma in situ) within the past 5 years; 4. Complicated with intestinal obstruction, intestinal perforation, gastrointestinal bleeding and other patients requiring emergency surgery; 5. pregnant or lactating women; 6. Patients with a history of severe mental illness, immune disease, hormone medication; 7. Patients contraindicated by MRI examination, chemoradiotherapy, immunotherapy or surgery; 8. Participated in other clinical researchers in the past 3 months; 9. Any other circumstances that the investigator considers inappropriate for inclusion.