Clinical Research Directory

Inclusion Criteria: 1. patients with AD whose clinical dementia rating (CDR) is \> 1 2. Spouses of Patients in the above group Or 3. Healthy adult unrelated to groups 1 and 2, with no history of dementia And 4. Regardless of the grouping, the prospective subject must be between 65 and 90 years old Exclusion Criteria: 1. Familial Alzheimer's Disease (AD) 2. Severe cardiovascular disease 3. Severe respiratory system disease 4. Severe liver disease 5. Severe kidney disease 6. Severe central nervous system diseases 7. Having a lifespan of fewer than 3 months 8. History of psychiatric illness 9. Major neurological diseases other than AD 10. Current use of corticosteroids, antibiotics, or bowel motility modification agents 11. Any history of Alcoholism or illicit drug dependence 12. Previous inclusion in this study 13. Difficulty with follow-up or poor compliance 14. Severe hearing impairment 15. Severe vision impairment