Clinical Research Directory

Inclusion Criteria: 1. Diagnosis of acute leukemia, myelodysplastic syndrome, chronic myelomonocytic leukemia (CMML) or myeloproliferative syndrome according to the WHO classification 2016, 2. Patient for whom a new line of therapy is initiated. 3. Patient older than 18 years of age. 4. Patient affiliated to the social security system or benefiting from such a system. 5. Signed consent to participate. Exclusion Criteria: 1. Weight at inclusion \< 50 kg 2. Participating in another clinical study that would cause the total amount of blood collection to exceed the and endanger the patient 3. Person in an emergency situation, adult under legal protection (guardianship, curatorship, etc.) protection (guardianship, curatorship or safeguard of justice), or unable to express his or her consent. 4. Impossibility to submit to the medical follow-up of the trial for geographical social or psychological reasons, 5. Pregnant or breastfeeding women