Clinical Research Directory

Inclusion Criteria: 1. Age older than 18 years of age; 2. Histologically or cytological confirmed gastric or gastroesophageal junction adenocarcinoma; 3. Without prior systematic therapy; 4. The Eastern Cooperative Oncology Group Performance status (ECOG PS) 0-1; 5. With measurable lesions according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; 6. Clinically diagnosed stage cT3-4bN1-3M0 evaluated by CT/MRI/EUS; 7. Life expectancy longer than 12 months; 8. Adequate function of blood, heart, liver, kidney and thyroid. Exclusion Criteria: 1. History of immunodeficiency, including HIV positive, or other acquired or congenital immunodeficiency disease, or history of organ transplantation or allogeneic bone marrow transplantation; 2. Unresectable tumor evaluated by investigator; 3. Present of poorly controlled cardiac symptoms or disease, including but not limited to: (1) heart failure with NYHA class II or above (2) unstable angina, （3）myocardial infarction occurred within 1 year (4) clinical significance supraventricular or ventricular arrhythmias without clinical intervention or poorly controlled after clinical intervention; 4. With tumors in other sites; 5. History of any active autoimmune disease, including but not limited to: interstitial pneumonia, enteritis, hepatitis, hypohysitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism (may be considered after hormone replacement therapy);Patients with psoriasis or childhood asthma/allergy who have been in complete remission and do not need any intervention as adults may be considered for inclusion, but patients requiring medical intervention with bronchodilators may not be included; 6. Has a history of allergy to monoclonal antibody, any component of PD-1 Inhibitor, S-1 and oxaliplatin; 7. With any mental illness; 8. Pregnant or lactating women.