Clinical Research Directory

Inclusion Criteria: 1. Provision of signed and dated informed consent 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Male or Female, aged 18 yrs or older 4. Diabetes diagnosed or meets ADA criteria for Type 2 diabetes 5. Foot ulcer of diabetic etiology, with all of the following characteristics: * Ulcer size \> 0.5cm2 and \< 12cm2 at least 2 cm from any other ulcer * Ulcer with Wagner grade 1 or 2 6. In case of multiple ulcers, select the largest ulcer that meets inclusion criteria. Exclusion Criteria: 1. Patient participating in an interventional clinical trial within 1 month of visit 1 2. Participant has Charcot's foot or other foot deformities that prevent adequate targeted ulcer offloading 3. Participant has active severe infection or osteomyelitis at the time of the screening visit 4. History of cancer within the last 3 years, other than non-melanoma skin cancer 5. Use of adjunctive therapy within previous 30 days 6. Currently receiving medication considered to be a systemic glucocorticoid 7. Plan to perform a vascular intervention, such as surgical bypass, angioplasty or stenting, or \< 1 month from a prior ipsilateral (same side) vascular intervention 8. Pregnant or currently lactating 9. Uncontrolled blood glucose with presence of urinary ketones 10. Contraindications for exercise as define by the American Heart Association/American College of Sports Medicine Guidelines for Exercise Testing and Prescription \[1\] 11. Bilateral wound or ulcer 12. Current infection of COVID19 13. Any history of concomitant medical condition that, in the opinion of the investigator(s), would compromise the participants ability to safely complete the study