Clinical Research Directory

Group 1 (HT already performed prior to diagnosis) Inclusion criteria • Aged 16 or over Papillary thyroid cancer: * pT1b-2 (≤4cm) irrespective of molecular genetic markers * R0 resection (clinically excised but microscopic R1 resected tumours at discretion of the local MDT) * cN0 or pN0, pNX \& pN1a (≤5 foci, no extranodal spread) * Confined to thyroid or minimal extrathyroidal extension * No higher risk histological variants on morphology (small foci allowed at the discretion of the local MDT) * No angioinvasion NB. PTC is still eligible where microscopic invasion of endothelial lined small capillary vascular spaces and lymphatic channels are present. It becomes ineligible in the rare instances when there is definite invasion of a larger vascular structure such as a vein with smooth muscle in its wall. * Encapsulated FVPTC with capsular invasion only * Micro-PTC (≤1cm) * multifocal * unifocal with pN1a (≤5 foci; no extranodal spread) Follicular thyroid cancer (FTC), including oncocytic or Hürthle cell carcinoma: * pT1b-2 (≤4cm) irrespective of molecular genetic markers \- Minimally invasive, with capsular invasion +/- minimal (≤4 foci) vascular invasion (the latter is now called encapsulated angioinvasive and is at the discretion of the MDT) * Confined to thyroid or minimal extrathyroidal extension Exclusion criteria * \>4cm * unifocal pT1a (≤1cm) PTC or FTC (unless pN1a as above) * NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) * Anaplastic, poorly differentiated or medullary thyroid carcinoma * R2 * gross extrathyroidal extension * pT4 or macroscopic tumour invasion of loco-regional tissues or structures * pN1a with \>5 foci or extranodal spread * pN1b * M1 * Aggressive PTC with any of the following features: * Widely invasive * Poorly differentiated * Anaplastic * predominance of Tall cell, Columnar cell, Hobnail, Diffuse sclerosing and other higher risk variants * FTC, including oncocytic or Hürthle cell cancer with any of the following features: * Minimally invasive with extensive vascular invasion (now called encapsulated angioinvasive) (\>4 foci) * Widely invasive * Poorly differentiated * Anaplastic Group 2 (DTC on cytology or after core biopsy, who has not had prior thyroid surgery yet) Inclusion criteria * Aged 16 or over * 'low risk' differentiated thyroid cancer confirmed by cytology or core biopsy. * cT1b-2 irrespective of molecular genetic markers * cN0 * Contralateral lobe without suspicious nodule(s) (U2, or U3/U4 with Thy2 on FNAC) Exclusion criteria • M1