Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Novel Limb Cryocompression System for Prevention of Chemotherapy Induced Peripheral Neuropathy - Expansion Study
Sponsor: National University Hospital, Singapore
Summary
The study conducted on cancer patients is designed to test safety and efficacy of limb hypothermia in cancer patients using the new Paxman Limb Cryocompression System (PLCS). Ultimately this will lead to the development of a therapy regime that will help to prevent chemotherapy-induced neuropathy in cancer patients.
Key Details
Gender
All
Age Range
21 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2022-11-11
Completion Date
2026-11
Last Updated
2025-09-23
Healthy Volunteers
No
Interventions
Paxman Limb Cryocompression System (PLCS)
The study population will comprise of cancer patients scheduled to receive weekly paclitaxel chemotherapy for a maximum of 12 cycles. Cryocompression will be applied during every cycle of chemotherapy for a duration of up to 4 hours. All chemotherapy patients will receive 30 minutes pre-infusion cooling and 30 minutes post-infusion cooling. Cryocompression for each cycle will not exceed 4 hours. Chemotherapy and concomitant limb cryocompression are performed for 12 cycles and may be continued further in consultation with the PI. Overall, limb cryocompression will be administered for no longer than four hours.
Locations (2)
National University Hospital
Singapore, Singapore, Singapore
Curie Oncology, Mount Elizabeth Novena Specialist Centre
Singapore, Singapore, Singapore