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Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)
Sponsor: ArriVent BioPharma, Inc.
Summary
Global, Phase 3, randomized, multicenter, open-label study evaluating the efficacy and safety of furmonertinib (firmonertinib) at 2 dose levels (160 mg once daily \[QD\] and 240 mg QD) compared to platinum-based chemotherapy in previously untreated patients with locally advanced or metastatic non-squamous Non-Small Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) exon 20 insertion mutations. A target of approximately 375 patients will be randomized in a 1:1:1 ratio to treatment with furmonertinib 240 mg QD, furmonertinib 160 mg QD, or platinum-based chemotherapy.
Official title: A Global, Phase 3, Randomized, Multicenter, Open-Label Study to Investigate the Efficacy and Safety of Furmonertinib Compared to Platinum-Based Chemotherapy as First-Line Treatment for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
398
Start Date
2023-06-01
Completion Date
2028-02-15
Last Updated
2025-06-22
Healthy Volunteers
No
Conditions
Interventions
furmonertinib 240 mg oral, daily
furmonertinib tablet
furmonertinib 160 mg oral, daily
furmonertinib tablet
platinum-based chemotherapy
(carboplatin or cisplatin based on investigator's choice) + pemetrexed intravenously (IV)
Locations (208)
Arrivent Investigative Site
Daphne, Alabama, United States
Arrivent Investigative Site
Yuma, Arizona, United States
Arrivent Investigative Site
Fayetteville, Arkansas, United States
Arrivent Investigative Site
Beverly Hills, California, United States
Arrivent Investigative Site
Fullerton, California, United States
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Long Beach, California, United States
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Los Alamitos, California, United States
Arrivent Investigative Site
Napa, California, United States
Arrivent Investigative Site
Orange, California, United States
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Orange, California, United States
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Sacramento, California, United States
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San Diego, California, United States
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Santa Barbara, California, United States
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Santa Monica, California, United States
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Santa Rosa, California, United States
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Whittier, California, United States
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Hartford, Connecticut, United States
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Norwich, Connecticut, United States
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Fort Myers, Florida, United States
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St. Petersburg, Florida, United States
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The Villages, Florida, United States
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Peoria, Illinois, United States
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Rolling Meadows, Illinois, United States
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Fort Wayne, Indiana, United States
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Indianapolis, Indiana, United States
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South Bend, Indiana, United States
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Bethesda, Maryland, United States
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Frederick, Maryland, United States
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Rockville, Maryland, United States
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Fairhaven, Massachusetts, United States
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Lansing, Michigan, United States
Arrivent Investigative Site
Bolivar, Missouri, United States
Arrivent Investigative Site
Kansas City, Missouri, United States
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Saint Joseph, Missouri, United States
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St Louis, Missouri, United States
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Omaha, Nebraska, United States
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Belleville, New Jersey, United States
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Englewood, New Jersey, United States
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Florham Park, New Jersey, United States
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The Bronx, New York, United States
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Goldsboro, North Carolina, United States
ArriVent Investigative Site
Pinehurst, North Carolina, United States
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Canton, Ohio, United States
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Cincinnati, Ohio, United States
ArriVent Investigative Site
Cincinnati, Ohio, United States
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Cleveland, Ohio, United States
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Columbus, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Tulsa, Oklahoma, United States
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Salem, Oregon, United States
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Gettysburg, Pennsylvania, United States
ArriVent Investigative Site
Langhorne, Pennsylvania, United States
Arrivent Investigative Site
York, Pennsylvania, United States
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Greenville, South Carolina, United States
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Sioux Falls, South Dakota, United States
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Memphis, Tennessee, United States
ArriVent Investigative Site
Nashville, Tennessee, United States
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Abilene, Texas, United States
ArriVent Investigative Site
Austin, Texas, United States
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Houston, Texas, United States
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Plano, Texas, United States
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Ogden, Utah, United States
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Salt Lake City, Utah, United States
ArriVent Investigative Site
Fairfax, Virginia, United States
Arrivent Investigative Site
Fredericksburg, Virginia, United States
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Bellingham, Washington, United States
Arrivent Investigative Site
Spokane Valley, Washington, United States
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Tacoma, Washington, United States
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Appleton, Wisconsin, United States
ArriVent Investigative Site
Heidelberg, Victoria, Australia
Arrivent Investigative Site
Blacktown, Australia
Arrivent Investigative Site
St Leonards, Australia
Arrivent Investigative Site
Woolloongabba, Australia
ArriVent Investigative Site
Salvador, Estado de Bahia, Brazil
ArriVent Investigative Site
Belo Horizonte, Minas Gerais, Brazil
ArriVent Investigative Site
Rio de Janeiro, Rio de Janeiro, Brazil
ArriVent Investigative Site
Rio de Janeiro, Rio de Janeiro, Brazil
ArriVent Investigative Site
Pelotas, Rio Grande do Sul, Brazil
ArriVent Investigative Site
Porto Alegre, Rio Grande, Brazil
ArriVent Investigative Site
Blumenau, SC Cep, Brazil
ArriVent Investigative Site
São José do Rio Preto, São Paulo, Brazil
ArriVent Investigative Site
São Paulo, São Paulo, Brazil
ArriVent Investigative Site
Liberdade, São Paulo/SP, Brazil
ArriVent Investigative Site
Taubaté, Taubate SP, Brazil
ArriVent Investigative Site
Porto Alegre, Brazil
ArriVent Investigative Site
Edmonton, Alberta, Canada
ArriVent Investigative Site
Toronto, Ontario, Canada
Allist Investigative Site
Beijing, Beijing Municipality, China
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Meizhou, Guangdong, China
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Xuhui, Hai City, China
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Hangzhou, Hangzhou, China
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Cangzhou, Hebei, China
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Shushan, Hefei, China
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Zhengzhou, Henan, China
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Changchun, Jilin, China
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Weihai, Lingang Economic and Technological Development Zo, China
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Nanning, Nanning, China
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Yangpu, Shanghai Municipality, China
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Xi’an, Shanxi, China
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Taiyuan, Taiyuan, China
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Kunming, Yunnan, China
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Zhejiang, Zhejiang, China
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Anyang, China
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Changchun, China
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Changsha, China
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Changsha, China
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Chengdu, China
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Chenzhou, China
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Chongqing, China
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Guangzhou, China
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Guangzhou, China
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Harbin, China
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Hefei, China
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Huai'an, China
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Huizhou, China
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Jinan, China
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Jinan, China
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Jining, China
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Lanzhou, China
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Lishui, China
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Luoyang, China
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Nanchang, China
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Nanchang, China
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Nanjing, China
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Ningbo, China
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Shanghai, China
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Shantou, China
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Shenyang, China
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Shenzhen, China
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Taiyuan, China
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Tianjin, China
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Weihui, China
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Wuhan, China
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Xiamen, China
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Xianyang, China
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Xinxiang, China
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Xuzhou, China
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Zhengzhou, China
Arrivent Investigative Site
Caen, France
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Lyon, France
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Lyon, France
Arrivent Investigative Site
Marseille, France
Arrivent Investigative Site
Toulouse, France
Arrivent Investigative Site
Villejuif, France
ArriVent Investigative Site
Beersheba, Israel
ArriVent Investigative Site
Haifa, Israel
ArriVent Investigative Site
Jerusalem, Israel
ArriVent Investigative Site
Rozzano, Milan, Italy
ArriVent Investigative Site
Aviano, PN, Italy
ArriVent Investigative Site
Roma, Rome, Italy
ArriVent Investigative Site
Bari, Italy
Arrivent Investigative Site
Meldola, Italy
ArriVent Investigative Site
Milan, Italy
ArriVent Investigative Site
Kurume, Fukuoka, Japan
Arrivent Investigative Site
Akashi, Japan
Arrivent Investigative Site
Hirakata, Japan
Arrivent Investigative Site
Kashiwa, Japan
Arrivent Investigative Site
Nagoya, Japan
Arrivent Investigative Site
Ōsaka-sayama, Japan
Arrivent Investigative Site
Sapporo, Japan
Arrivent Investigative Site
Sendai, Japan
Arrivent Investigative Site
Shizuoka, Japan
Arrivent Investigative Site
Tokyo, Japan
ArriVent Investigative Site
Tokyo, Japan
Arrivent Investigative Site
Ube, Japan
Arrivent Investigative Site
Yokohama, Japan
ArriVent Investigative Site
George Town, Pulau Pinang, Malaysia
Arrivent Investigative Site
Cheras, Malaysia
Arrivent Investigative Site
Kota Bharu, Malaysia
Arrivent Investigative Site
Kuala Lumpur, Malaysia
Arrivent Investigative Site
Kuching, Malaysia
ArriVent Investigative Site
Tuxtla Gutiérrez, Chiapas, Mexico
ArriVent Investigative Site
Mexico City, Mexico City, Mexico
Arrivent Investigative Site
Amsterdam, Netherlands
Arrivent Investigative Site
Harderwijk, Netherlands
Arrivent Investigative Site
Cebu, Philippines
Arrivent Investigative Site
Davao City, Philippines
ArriVent Investigative Site
Manila, Philippines
Arrivent Investigative Site
Pasig, Philippines
ArriVent Investigative Site
Singapore, Singapore
Arrivent Investigative Site
Singapore, Singapore
ArriVent Investigative Site
Jungni I Gu, Seoul, South Korea
Arrivent Investigative Site
Busan, South Korea
Arrivent Investigative Site
Hwasun, South Korea
Arrivent Investigative Site
Seoul, South Korea
Arrivent Investigative Site
Seoul, South Korea
Arrivent Investigative Site
Seoul, South Korea
Arrivent Investigative Site
Seoul, South Korea
ArriVent Investigative Site
Málaga, Malaga, Spain
Arrivent Investigative Site
A Coruña, Spain
Arrivent Investigative Site
Barcelona, Spain
ArriVent Investigative Site
Madrid, Spain
Arrivent Investigative Site
Valencia, Spain
Arrivent Investigative Site
Chang-hua, Taiwan
Arrivent Investigative Site
Kaohsiung City, Taiwan
ArriVent Investigative Site
Kaohsiung City, Taiwan
ArriVent Investigative Site
Taichung, Taiwan
Arrivent Investigative Site
Tainan, Taiwan
Arrivent Investigative Site
Taipei, Taiwan
Arrivent Investigative Site
Bangkok, Thailand
Arrivent Investigative Site
Bangkok, Thailand
Arrivent Investigative Site
Bangkok, Thailand
Arrivent Investigative Site
Hat Yai, Thailand
ArriVent Investigative Site
Guildford, Surrey, United Kingdom
Arrivent Investigative Site
Bebington, Wirral, United Kingdom
ArriVent Investigative Site
London, United Kingdom
ArriVent Investigative Site
Manchester, United Kingdom
ArriVent Investigative Site
Sutton, United Kingdom