Clinical Research Directory
Browse clinical research sites, groups, and studies.
Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
Sponsor: Mirati Therapeutics Inc.
Summary
Study CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the first-line setting for patients with advanced NSCLC with TPS ≥ 1%, TPS \<50% and KRAS G12C mutation
Official title: A Phase 2 Trial of Combination Therapies With Adagrasib in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2022-11-22
Completion Date
2026-12-01
Last Updated
2025-08-17
Healthy Volunteers
No
Conditions
Interventions
Adagrasib oral dose of 400 mg twice daily tablets
oral dose of 400 mg twice daily tablets
Pembrolizumab
IV infusion once every 3 weeks
Chemotherapy: Pemetrexed
IV infusion once every 3 weeks
Cisplatin/Carboplatin
IV infusion once every 3 weeks
Locations (166)
Local Institution - Unk025
Anchorage, Alaska, United States
Local Institution - 017-591
Glendale, Arizona, United States
Local Institution - 017-821
Phoenix, Arizona, United States
Local Institution - Unk047
Anaheim, California, United States
Local Institution - 017-936C
Fountain Valley, California, United States
MemorialCare - Orange Coast Medical Center
Fountain Valley, California, United States
Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton
Fullerton, California, United States
Local Institution - Unk004
Loma Linda, California, United States
Local Institution - 017-961
Los Angeles, California, United States
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States
Local Institution - 017-872-I
Aurora, Colorado, United States
Local Institution - 017-872-G
Boulder, Colorado, United States
Local Institution - 017-872-D
Colorado Springs, Colorado, United States
Local Institution - 017-872-J
Colorado Springs, Colorado, United States
Local Institution - 017-872-B
Denver, Colorado, United States
Local Institution - 017-872-F
Denver, Colorado, United States
Local Institution - 017-872-A
Lakewood, Colorado, United States
Local Institution - 017-872-C
Littleton, Colorado, United States
USOR - Rocky Mountain Cancer Centers - Lone Tree - Sky Ridge Medical Center
Lone Tree, Colorado, United States
Local Institution - 017-872-E
Pueblo, Colorado, United States
Local Institution - 017-872-H
Thornton, Colorado, United States
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States
The Oncology Institute of Hope and Innovation - Lakeland
Lakeland, Florida, United States
Local Institution - Unk076
Miami, Florida, United States
Local Institution - Unk055
Orlando, Florida, United States
Local Institution - Unk062
Chicago, Illinois, United States
University of Chicago
Chicago, Illinois, United States
Local Institution - 017-820J
Fairway, Kansas, United States
Local Institution - 017-820A
Kansas City, Kansas, United States
Local Institution - 017-820B
Kansas City, Kansas, United States
Local Institution - 017-820C
Kansas City, Kansas, United States
Local Institution - 017-820H
Kansas City, Kansas, United States
Local Institution - 017-820I
Overland Park, Kansas, United States
University of Kansas Cancer Center - Westwood/Richard and Annette Bloch Cancer Care Pavilion
Westwood, Kansas, United States
Local Institution - 017-965
Lexington, Kentucky, United States
Local Institution - Unk009
Baltimore, Maryland, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Local Institution - Unk039
Burlington, Massachusetts, United States
Local Institution - Unk069
Detroit, Michigan, United States
Local Institution - Unk018
Lansing, Michigan, United States
Henry Ford Medical Center - Columbus
Novi, Michigan, United States
Local Institution - 017-838B
Minneapolis, Minnesota, United States
Local Institution - 017-838C
Minneapolis, Minnesota, United States
Mayo Clinic - Rochester
Rochester, Minnesota, United States
Metro-Minnesota Community Oncology Research Consortium (MMCORC)
Saint Louis Park, Minnesota, United States
Local Institution - 017-838A
Saint Louis Park, Minnesota, United States
Local Institution - 017-820F
Kansas City, Missouri, United States
Local Institution - 017-820E
Kansas City, Missouri, United States
Local Institution - 017-820D
Lee's Summit, Missouri, United States
Local Institution - 017-820G
North Kansas City, Missouri, United States
Local Institution - Unk008
Osage Beach, Missouri, United States
Local Institution - Unk058
Springfield, Missouri, United States
Local Institution - 017-080
Babylon, New York, United States
Local Institution - 017-088
Brooklyn, New York, United States
Hematology-Oncology Associates of Central New York - Brittonfield - East Syracuse
East Syracuse, New York, United States
Local Institution - 017-087
New Hyde Park, New York, United States
Local Institution - 017-085
New York, New York, United States
Local Institution - 017-082
Patchogue, New York, United States
Local Institution - 017-086
Port Jefferson, New York, United States
Local Institution - 017-081
Port Jefferson Station, New York, United States
New York Cancer & Blood Specialists - Cancer Center - Research Headquarters
Port Jefferson Station, New York, United States
Local Institution - 017-084
Riverhead, New York, United States
Local Institution - 017-945
The Bronx, New York, United States
Local Institution - 017-083
The Bronx, New York, United States
Cleveland Clinic Main Campus
Cleveland, Ohio, United States
Local Institution - 017-836
Kettering, Ohio, United States
Local Institution - 017-916
Memphis, Tennessee, United States
Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center
Dallas, Texas, United States
Local Institution - Unk056
Dallas, Texas, United States
Local Institution - 017-848
Houston, Texas, United States
Local Institution - 017-999
Irving, Texas, United States
USOR - Texas Oncology Northeast Texas - Longview Cancer Center
Longview, Texas, United States
Local Institution - 017-878-B
Palestine, Texas, United States
Local Institution - 017-878-C
Paris, Texas, United States
Local Institution - 017-878-A
Tyler, Texas, United States
Local Institution - Unk010
Salt Lake City, Utah, United States
Local Institution - 017-814-A
Arlington, Virginia, United States
Local Institution - Unk066
Fairfax, Virginia, United States
Virginia Cancer Specialists - Fairfax Office
Fairfax, Virginia, United States
Local Institution - 017-814-B
Gainesville, Virginia, United States
Local Institution - 017-814-C
Reston, Virginia, United States
PeaceHealth St. Joseph Medical Center
Bellingham, Washington, United States
Local Institution - Unk036
Huntington, West Virginia, United States
Local Institution - 017-458
Natal, Rio Grande do Norte, Brazil
Local Institution - 017-446
Ijuí, Rio Grande do Sul, Brazil
Local Institution - 017-453
Itajaí, Santa Catarina, Brazil
Local Institution - 017-457
Barretos, Brazil
Local Institution - 017-442
Curitiba, Brazil
Local Institution - 017-452
Fortaleza, Brazil
Local Institution - 017-455
Jaú, Brazil
Local Institution - 017-454
Rio de Janeiro, Brazil
Local Institution - 017-456
São Paulo, Brazil
Local Institution - 017-695
Viña del Mar, Región de Valparaíso, Chile
Local Institution - 017-697
Providencia, Chile
Local Institution - 017-696
Santiago, Chile
Local Institution - 017-698
Temuco, Chile
Institut de Cancerologie de lOuest - Angers
Angers, France
Centre Francois Baclesse
Caen, France
Centre Hospitalier Intercommunal de Creteil
Créteil, France
Centre Georges Francois Leclerc
Dijon, France
Hopital Michallon
La Tronche, France
Local Institution - 017-688
Lille, France
Local Institution - Unk078
Lyon, France
Institut Paoli-Calmettes
Marseille, France
Local Institution - Unk067
Marseille, France
Local Institution - 017-200
Montpellier, France
Local Institution - Unk029
Paris, France
Hopital Tenon
Paris, France
Local Institution - 017-664
Paris, France
Local Institution - 017-198
Saint-Herblain, France
Hopital Foch
Suresnes, France
Hopital Larrey
Toulouse, France
Gustave Roussy
Villejuif, France
Local Institution - 017-790
Batumi, Georgia
Local Institution - 017-789
Tbilisi, Georgia
Local Institution - 017-794
Tbilisi, Georgia
Local Institution - 017-791
Tbilisi, Georgia
Local Institution - 017-792
Tbilisi, Georgia
Local Institution - 017-793
Tbilisi, Georgia
University General Hospital of Heraklion (PAGNI)
Heraklion, Greece
University General Hospital of Larissa
Larissa, Greece
Metropolitan Hospital
Piraeus, Greece
Orszagos Koranyi Pulmonologiai Intezet
Budapest, Hungary
Orszagos Onkologiai Intezet
Budapest, Hungary
Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz
Székesfehérvár, Hungary
Reformatus Pulmonologiai Centrum
Törökbálint, Hungary
Local Institution - 017-767 - B
Faenza, Ravenna, Italy
Local Institution - 017-767 - A
Lugo, Ravenna, Italy
Azienda Ospedaliera San Giuseppe Moscati - Avellino
Avellino, Italy
Local Institution - 017-274
Aviano, Italy
Ospedale Santo Spirito
Casale Monferrato, Italy
Azienda Ospedaliero - Universitaria Careggi
Florence, Italy
Istituto Europeo di Oncologia
Milan, Italy
Azienda Ospedaliero - Universitaria San Luigi Gonzaga
Orbassano, Italy
Local Institution - 017-297
Padova, Italy
Ospedale Santa Maria delle Croci di Ravenna
Ravenna, Italy
IRCCS Istituto Nazionale Tumori Regina Elena
Roma, Italy
Local Institution - 017-280
Roma, Italy
Local Institution - 017-076
Kota Bharu, Kelantan, Malaysia
Local Institution - 017-075
Kuantan, Pahang, Malaysia
Local Institution - 017-073
Kuala Lumpur, Malaysia
Local Institution - 017-072
Putrajaya, Malaysia
Local Institution - 017-381
Konin, Poland
Instytut MSF
Lodz, Poland
Med Polonia Sp. z o. o. - Obornicka
Poznan, Poland
Wojskowy Instytut Medyczny
Warsaw, Poland
Local Institution - 017-692
Belgrade, Serbia
Local Institution - 017-693
Belgrade, Serbia
Local Institution - 017-690
Belgrade, Serbia
Local Institution - 017-691
Kamenitz, Serbia
Local Institution - 017-694
Kragujevac, Serbia
Complejo Hospitalario Universitario A Coruna
A Coruña, Spain
Hospital General Universitario Gregorio Maranon
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
Hospital Universitario Puerta de Hierro - Majadahonda
Majadahonda, Spain
Local Institution - Unk001
Málaga, Spain
Hospital Universitario Son Espases
Palma de Mallorca, Spain
Hospital Son Llatzer
Palma de Mallorca, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Hospital Clinico Universitario Lozano Blesa
Zaragoza, Spain
Local Institution - 017-395
Geneva, Switzerland
Local Institution - 017-132
Bang Phlat, Thailand
Local Institution - 017-136
Bangkok, Thailand
Local Institution - 017-135
Chom Thong, Thailand
Local Institution - 017-137
Khon Kaen, Thailand