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Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
Sponsor: Mirati Therapeutics Inc.
Summary
Study CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the first-line setting for patients with advanced NSCLC with TPS ≥ 1%, TPS \<50% and KRAS G12C mutation
Official title: A Phase 2 Trial of Combination Therapies With Adagrasib in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2022-11-22
Completion Date
2026-12-01
Last Updated
2026-06-23
Healthy Volunteers
No
Conditions
Interventions
Adagrasib oral dose of 400 mg twice daily tablets
oral dose of 400 mg twice daily tablets
Pembrolizumab
IV infusion once every 3 weeks
Chemotherapy: Pemetrexed
IV infusion once every 3 weeks
Cisplatin/Carboplatin
IV infusion once every 3 weeks
Locations (94)
Local Institution - 017-936C
Fountain Valley, California, United States
Local Institution - 017-936
Fountain Valley, California, United States
Local Institution - 017-851
Fullerton, California, United States
Local Institution - 017-540
San Francisco, California, United States
Local Institution - 017-872-I
Aurora, Colorado, United States
Local Institution - 017-872-G
Boulder, Colorado, United States
Local Institution - 017-872-D
Colorado Springs, Colorado, United States
Local Institution - 017-872-J
Colorado Springs, Colorado, United States
Local Institution - 017-872-B
Denver, Colorado, United States
Local Institution - 017-872-F
Denver, Colorado, United States
Local Institution - 017-872-A
Lakewood, Colorado, United States
Local Institution - 017-872-C
Littleton, Colorado, United States
Local Institution - 017-872
Lone Tree, Colorado, United States
Local Institution - 017-872-E
Pueblo, Colorado, United States
Local Institution - 017-872-H
Thornton, Colorado, United States
Local Institution - 017-829
Jacksonville, Florida, United States
Local Institution - 017-898
Lakeland, Florida, United States
Local Institution - 017-972
Chicago, Illinois, United States
Local Institution - 017-820J
Fairway, Kansas, United States
Local Institution - 017-820A
Kansas City, Kansas, United States
Local Institution - 017-820B
Kansas City, Kansas, United States
Local Institution - 017-820C
Kansas City, Kansas, United States
Local Institution - 017-820H
Kansas City, Kansas, United States
Local Institution - 017-820I
Overland Park, Kansas, United States
Local Institution - 017-820
Westwood, Kansas, United States
Local Institution - 017-388
Boston, Massachusetts, United States
Local Institution - 017-808
Boston, Massachusetts, United States
Local Institution - 017-811
Novi, Michigan, United States
Local Institution - 017-838B
Minneapolis, Minnesota, United States
Local Institution - 017-838C
Minneapolis, Minnesota, United States
Local Institution - 017-830
Rochester, Minnesota, United States
Local Institution - 017-838
Saint Louis Park, Minnesota, United States
Local Institution - 017-838A
Saint Louis Park, Minnesota, United States
Local Institution - 017-820F
Kansas City, Missouri, United States
Local Institution - 017-820E
Kansas City, Missouri, United States
Local Institution - 017-820D
Lee's Summit, Missouri, United States
Local Institution - 017-820G
North Kansas City, Missouri, United States
Local Institution - 017-080
Babylon, New York, United States
Local Institution - 017-088
Brooklyn, New York, United States
Local Institution - 017-587
East Syracuse, New York, United States
Local Institution - 017-087
New Hyde Park, New York, United States
Local Institution - 017-085
New York, New York, United States
Local Institution - 017-082
Patchogue, New York, United States
Local Institution - 017-086
Port Jefferson, New York, United States
Local Institution - 017-081
Port Jefferson Station, New York, United States
Local Institution - 017-535
Port Jefferson Station, New York, United States
Local Institution - 017-084
Riverhead, New York, United States
Local Institution - 017-083
The Bronx, New York, United States
Local Institution - 017-818
Cleveland, Ohio, United States
Local Institution - 017-879
Dallas, Texas, United States
Local Institution - 017-878
Longview, Texas, United States
Local Institution - 017-878-B
Palestine, Texas, United States
Local Institution - 017-878-C
Paris, Texas, United States
Local Institution - 017-878-A
Tyler, Texas, United States
Local Institution - 017-814-A
Arlington, Virginia, United States
Local Institution - 017-814
Fairfax, Virginia, United States
Local Institution - 017-814-B
Gainesville, Virginia, United States
Local Institution - 017-814-C
Reston, Virginia, United States
Local Institution - 017-909
Bellingham, Washington, United States
Local Institution - 017-689
Angers, France
Local Institution - 017-196
Caen, France
Local Institution - 017-190
Créteil, France
Local Institution - 017-192
Dijon, France
Local Institution - 017-683
La Tronche, France
Local Institution - 017-199
Marseille, France
Local Institution - 017-686
Paris, France
Local Institution - 017-667
Suresnes, France
Local Institution - 017-663
Toulouse, France
Local Institution - 017-202
Villejuif, France
Local Institution - 017-238
Heraklion, Greece
Local Institution - 017-235
Larissa, Greece
Local Institution - 017-234
Piraeus, Greece
Local Institution - 017-244
Budapest, Hungary
Local Institution - 017-241
Budapest, Hungary
Local Institution - 017-759
Székesfehérvár, Hungary
Local Institution - 017-240
Törökbálint, Hungary
Local Institution - 017-292
Avellino, Italy
Local Institution - 017-773
Casale Monferrato, Italy
Local Institution - 017-762
Florence, Italy
Local Institution - 017-278
Milan, Italy
Local Institution - 017-788
Orbassano, Italy
Local Institution - 017-767
Ravenna, Italy
Local Institution - 017-295
Roma, Italy
Local Institution - 017-757
Lodz, Poland
Local Institution - 017-382
Poznan, Poland
Local Institution - 017-774
Warsaw, Poland
Local Institution - 017-613
A Coruña, Spain
Local Institution - 017-619
Madrid, Spain
Local Institution - 017-624
Madrid, Spain
Local Institution - 017-626
Majadahonda, Spain
Local Institution - 017-602
Palma de Mallorca, Spain
Local Institution - 017-771
Palma de Mallorca, Spain
Local Institution - 017-772
Seville, Spain
Local Institution - 017-603
Zaragoza, Spain