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Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
Sponsor: Mercy Health Ohio
Summary
The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circulation and have a proximal carotid occlusive disease (occlusion or severe stenosis).
Key Details
Gender
All
Age Range
18 Years - 79 Years
Study Type
INTERVENTIONAL
Enrollment
404
Start Date
2024-05-08
Completion Date
2027-05-08
Last Updated
2025-12-17
Healthy Volunteers
No
Conditions
Interventions
MT+CAS with IV-AP
Mechanical Thrombectomy is a treatment for stroke that removes clots that block large blood vessels. Carotid stenting is a procedure that is deployed within the lumen of the carotid artery which treats the narrowing of the carotid artery. With added intravenous antiplatelet therapy.
MT+CAS with PO-AP
Mechanical Thrombectomy is a treatment for stroke that removes clots that block large blood vessels. Carotid stenting is a procedure that is deployed within the lumen of the carotid artery which treats the narrowing of the carotid artery. With added oral antiplatelet therapy.
MT+CAT with PO-AP
Mechanical Thrombectomy is a treatment for stroke that removes clots that block large blood vessels. Carotid stenting is a procedure that is deployed within the lumen of the carotid artery which treats the narrowing of the carotid artery. With added oral antiplatelet therapy
Locations (51)
Mobile Infirmary Medical Center
Mobile, Alabama, United States
Glendale Adventist Medical Center
Glendale, California, United States
University of California, Irvine
Irvine, California, United States
Pomona Valley
Pomona, California, United States
Sutter Institute for Medical Research
Sacramento, California, United States
California Pacific Medical Center/Mils Peninsula Medical Center
San Francisco, California, United States
Boca Raton - Baptist Health
Boca Raton, Florida, United States
Delray Medical Center
Delray Beach, Florida, United States
Baptist Health Research Institute
Jacksonville, Florida, United States
University of Florida Health Jacksonville
Jacksonville, Florida, United States
University of Miami School of Medicine
Miami, Florida, United States
Orlando Health, Inc.
Orlando, Florida, United States
University of South Florida
Tampa, Florida, United States
St. Mary's Medical Center
West Palm Beach, Florida, United States
Piedmont Healthcare
Atlanta, Georgia, United States
WellStar Health System, Inc
Marietta, Georgia, United States
Ascension/Alexian Brothers Health System
Chicago, Illinois, United States
University of Chicago
Chicago, Illinois, United States
Northwestern Medicine Central DuPage Hospital
Winfield, Illinois, United States
Indiana University Health Methodist Hospital
Indianapolis, Indiana, United States
Munster Community Hospital
Munster, Indiana, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
Baptist Healthcare Systems, Inc
Lexington, Kentucky, United States
Ochsner Medical Center
New Orleans, Louisiana, United States
Louisiana State University Health Sciences Center at Shreveport
Shreveport, Louisiana, United States
Boston Medical Center
Boston, Massachusetts, United States
University of Massachusetts
Worcester, Massachusetts, United States
McLaren Flint
Flint, Michigan, United States
Bronson Methodist Hospital/Western Michigan University Homer Stryker M.D. School of Medicine
Kalamazoo, Michigan, United States
Michigan State University
Lansing, Michigan, United States
McLaren Macomb
Mount Clemens, Michigan, United States
SSM Health DePaul Hospital
St Louis, Missouri, United States
JFK University Medical Center
Edison, New Jersey, United States
Rutgers, The State University
Piscataway, New Jersey, United States
Albany Medical College
Albany, New York, United States
Northwell Health- South Shore University Hospital
Bay Shore, New York, United States
Mount Sinai Hospital
New York, New York, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
OhioHealth Research Institute
Columbus, Ohio, United States
Mercy Health St. Vincent Medical Center
Toledo, Ohio, United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
Allegheny Health Network Research Institute
Pittsburgh, Pennsylvania, United States
WellSpan Health
York, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
Semmes-Murphey Foundation
Memphis, Tennessee, United States
DHR Health Institute for Research and Development
Edinburg, Texas, United States
HCA Houston Kingwood
Houston, Texas, United States
University of Utah
Salt Lake City, Utah, United States
Valley Medical Center
Renton, Washington, United States
University of Washington
Seattle, Washington, United States
West Virginia Univeristy
Morgantown, West Virginia, United States